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Valentina Uivarosi  - - - 
Top co-authors See all
Mihaela Badea

46 shared publications

Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, Bucharest, Romania

Rodica Olar

27 shared publications

Cellular Dynamics and Flow Cytometry Department, National Institute R&D for Biological Sciences, Bucharest, Romania

Constantin-Daniel Negut

16 shared publications

IRASM Radiation Processing Center, Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering (IFIN-HH), 30 Reactorului Str., P. O. Box MG-6, RO 077125 Bucharest Magurele, Ilfov, Romania, Tel.: +4021 404 2320, Fax: +4021 457 5331

Alexandra- Cristina Munteanu

5 shared publications

Department of General and Inorganic Chemistry, Faculty of Pharmacy; Carol Davila University of Medicine and Pharmacy; 6 Traian Vuia Str Bucharest 020956 Romania

Alexandra-Cristina Munteanu

1 shared publications

Department of General and Inorganic Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Str., 020956 Bucharest, Romania

17
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Distribution of Articles published per year 
(2010 - 2018)
Total number of journals
published in
 
11
 
Publications See all
BOOK-CHAPTER 0 Reads 0 Citations An Overview of Synthetic and Semisynthetic Flavonoid Derivatives and Analogues: Perspectives in Drug Discovery Valentina Uivarosi, Alexandra-Cristina Munteanu, George Miha... Published: 01 January 2018
Studies in Natural Products Chemistry, doi: 10.1016/b978-0-444-64181-6.00002-4
DOI See at publisher website
BOOK-CHAPTER 0 Reads 0 Citations Flavonoid Complexes as Promising Anticancer Metallodrugs Valentina Uivarosi, Alexandra‐Cristina Munteanu Published: 23 August 2017
Flavonoids - From Biosynthesis to Human Health, doi: 10.5772/67879
DOI See at publisher website
BOOK-CHAPTER 0 Reads 1 Citation Nanoformulation as a Tool for Improve the Pharmacological Profile of Platinum and Ruthenium Anticancer Drugs Valentina Uivarosi, Rodica Olar, Mihaela Badea Published: 23 August 2017
Descriptive Inorganic Chemistry Researches of Metal Compounds, doi: 10.5772/intechopen.68306
DOI See at publisher website
Article 0 Reads 5 Citations Development perspectives of silver complexes with antibacterial quinolones: Successful or not? Aura Rusu, Gabriel Hancu, Alexandra Cristina Munteanu, Valen... Published: 01 June 2017
Journal of Organometallic Chemistry, doi: 10.1016/j.jorganchem.2017.02.023
DOI See at publisher website
Article 0 Reads 2 Citations Synthesis and Structural Investigation of New Bio-Relevant Complexes of Lanthanides with 5-Hydroxyflavone: DNA Binding a... Alexandra-Cristina Munteanu, Mihaela Badea, Rodica Olar, Lui... Published: 16 December 2016
Molecules, doi: 10.3390/molecules21121737
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
In the present work, we attempted to develop new metal coordination complexes of the natural flavonoid 5-hydroxyflavone with Sm(III), Eu(III), Gd(III), Tb(III). The resultant hydroxo complexes have been characterized by a variety of spectroscopic techniques, including fluorescence, FT-IR, UV-Vis, EPR and mass spectral studies. The general chemical formula of the complexes is [Ln(C15H9O3)3(OH)2(H2O)x]·nH2O, where Ln is the lanthanide cation and x = 0 for Sm(III), x = 1 for Eu(III), Gd(III), Tb(III) and n = 0 for Sm(III), Gd(III), Tb(III), n = 1 for Eu(III), respectively. The proposed structures of the complexes were optimized by DFT calculations. Theoretical calculations and experimental determinations sustain the proposed structures of the hydroxo complexes, with two molecules of 5-hydroxyflavone acting as monoanionic bidentate chelate ligands. The interaction of the complexes with calf thymus DNA has been explored by fluorescence titration and UV-Vis absorption binding studies, and revealed that the synthesized complexes interact with DNA with binding constants (Kb) ~ 104. Human serum albumin (HSA) and transferrin (Tf) binding studies have also been performed by fluorescence titration techniques (fluorescence quenching studies, synchronous fluorescence spectra). The apparent association constants (Ka) and thermodynamic parameters have been calculated from the fluorescence quenching experiment at 299 K, 308 K, and 318 K. The quenching curves indicate that the complexes bind to HSA with smaller affinity than the ligand, but to Tf with higher binding affinities than the ligand.
Article 0 Reads 1 Citation New silver complexes with levofloxacin: Synthesis, characterization and microbiological studies Aura Rusu, Gabriel Hancu, Gergő Tóth, Szende Vancea, Felicia... Published: 01 November 2016
Journal of Molecular Structure, doi: 10.1016/j.molstruc.2016.07.035
DOI See at publisher website
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