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Francesco Testa  - - - 
Top co-authors See all
A. Vaccari

184 shared publications

University of Ferrara; Ferrara Italy

S Rossi

173 shared publications

University of Trento

M Rinaldi

152 shared publications

Sanger Heart & Vascular Institute, Charlotte, United States of America

Luigi Vitagliano

148 shared publications

Institute of Biostructures and Bioimaging (IBB), CNR; Via Mezzocannone 16 80134 Naples Italy

Paolo Grieco

139 shared publications

Department of Pharmacy, University of Naples “Federico II”, via D. Montesano 49, 80131 Naples, Italy

Publication Record
Distribution of Articles published per year 
(1970 - 2018)
Total number of journals
published in
Publications See all
Article 0 Reads 0 Citations Does Green Public Procurement lead to Life Cycle Costing (LCC) adoption? Maria Rosa De Giacomo, Francesco Testa, Fabio Iraldo, Marco ... Published: 01 May 2018
Journal of Purchasing and Supply Management, doi: 10.1016/j.pursup.2018.05.001
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Article 0 Reads 0 Citations Social Sustainability as Buying Local: Effects of Soft Policy, Meso-Level Actors, and Social Influences on Purchase Inte... Francesco Testa, Michael V. Russo, T. Bettina Cornwell, Aaro... Published: 01 April 2018
Journal of Public Policy & Marketing, doi: 10.1509/jppm.16.215
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Article 0 Reads 0 Citations Prevalence of macular abnormalities assessed by optical coherence tomography in patients with Usher syndrome Francesco Testa, Paolo Melillo, Settimio Rossi, Vincenzo Mar... Published: 13 July 2017
Ophthalmic Genetics, doi: 10.1080/13816810.2017.1329445
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Article 0 Reads 1 Citation High Levels of Serum Ubiquitin and Proteasome in a Case of HLA-B27 Uveitis Settimio Rossi, Carlo Gesualdo, Rosa Maisto, Maria Consiglia... Published: 26 February 2017
International Journal of Molecular Sciences, doi: 10.3390/ijms18030505
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In this paper, the authors describe a case of high serum levels of ubiquitin and proteasome in a woman under an acute attack of autoimmune uveitis. The woman was 52 years old, diagnosed as positive for the Human leukocyte antigen-B27 gene, and came to our observation in January 2013 claiming a severe uveitis attack that involved the right eye. During the acute attack of uveitis, this woman had normal serum biochemical parameters but higher levels of serum ubiquitin and proteasome 20S subunit, with respect to a healthy volunteer matched for age and sex. These levels correlated well with the clinical score attributed to uveitis. After the patient was admitted to therapy, she received oral prednisone in a de-escalation protocol (doses from 50 to 5 mg/day) for four weeks. Following this therapy, she had an expected reduction of clinical signs and score for uveitis, but concomitantly she had a reduction of the serum levels of ubiquitin, poliubiquitinated proteins (MAb-FK1) and proteasome 20S activity. Therefore, a role for ubiquitin and proteasome in the development of human autoimmune uveitis has been hypothesized.
Article 0 Reads 2 Citations Genetic characterization of Italian patients with Bardet-Biedl syndrome and correlation to ocular, renal and audio-vesti... Gabriella Esposito, Francesco Testa, Miriam Zacchia, Anna Al... Published: 01 February 2017
BMC Medical Genetics, doi: 10.1186/s12881-017-0372-0
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Background Bardet-Biedl syndrome (BBS) is a rare genetic disorder that features retinal degeneration, obesity, polydactyly, learning disabilities and renal abnormalities. The diagnosis is often missed at birth, the median age at diagnosis being 9 years. In the attempt to shed light on BBS and improve its diagnosis and treatment, we evaluated the genotype-phenotype relationship in patients with a molecular diagnosis of BBS. Methods We analyzed three common BBS genes, BBS1, BBS10 and BBS2, in 25 Italian patients fulfilling the clinical criteria of BBS. In 12 patients, we identified gene-specific biallelic variants and thus correlated genotype to the ophthalmic, renal and audio-vestibular phenotypes. Results At least one sequence variant was found in 60% of patients. The most common mutated gene was BBS1 followed by BBS10. Of the 17 sequence variants we found, 11 have not previously been associated with BBS. In 12 patients, we identified biallelic pathogenic variants; they had retinitis pigmentosa with early onset of visual impairment. However, retinal dystrophy was less severe in patients with BBS1 than in those with BBS10 variants. Overall, we found a high prevalence of renal dysmorphism and dysfunction. Notably, patients with BBS10 variants had the most severe renal impairment, which resulted in a critical decline in renal function. All the patients who underwent audio-vestibular evaluation had dysfunction of the cochlear outer hair cells, thus confirming the presence of hearing defects. Conclusion BBS1, BBS2 and BBS10 are major causative genes in Italian BBS patients. BBS10 was associated with the worse outcome in terms of the renal, ocular and audiovestibular phenotypes. Cochlear dysfunction should be included among the hallmarks of BBS. Keywords Bardet-Biedl syndrome BBS1, BBS2 and BBS10 gene variants Ciliopathy Renal, ocular and audiovestibular phenotype
Article 0 Reads 4 Citations The Effectiveness of EMAS as a Management Tool: A Key Role for the Internalization of Environmental Practices Francesco Testa, Fabio Iraldo, Tiberio Daddi Published: 17 January 2017
Organization & Environment, doi: 10.1177/1086026616687609
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