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Paul R. Jensen  - - - 
Top co-authors See all
‡ Pieter C. Dorrestein

256 shared publications

Collaborative Mass Spectrometry Innovation Center; Skaggs School of Pharmacy and Pharmaceutical Sciences; University of California; San Diego, La Jolla California 92093 United States

William Fenical

222 shared publications

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, La Jolla, San Diego, California 92093-0204, United States

Bradley S. Moore

180 shared publications

Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA, USA

Brian T. Murphy

34 shared publications

College of Pharmacy, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 900 South Ashland Avenue, Chicago, Illinois 60607, United States

Matthias Wietz

26 shared publications

Institute for Chemistry and Biology of the Marine Environment, University of Oldenburg, Germany

212
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Publication Record
Distribution of Articles published per year 
(1970 - 2019)
Total number of journals
published in
 
26
 
Publications See all
Article 0 Reads 0 Citations Diversity and distribution of the bmp gene cluster and its Polybrominated products in the genus Pseudoalteromonas Julia Busch, Vinayak Agarwal, Michelle Schorn, Henrique Mach... Published: 22 February 2019
Environmental Microbiology, doi: 10.1111/1462-2920.14532
DOI See at publisher website
Article 0 Reads 0 Citations Nitrosopyridine Probe To Detect Polyketide Natural Products with Conjugated Alkenes: Discovery of Novodaryamide and Noca... Gabriel Castro-Falcón, Natalie Millán Aguiñaga, Catherine Ro... Published: 01 October 2018
ACS Chemical Biology, doi: 10.1021/acschembio.8b00598
DOI See at publisher website
Article 0 Reads 1 Citation Integration of Genomic Data with NMR Analysis Enables Assignment of the Full Stereostructure of Neaumycin B, a Potent In... Min Cheol Kim, Henrique Machado, Kyoung Hwa Jang, Lynnie Trz... Published: 07 August 2018
Journal of the American Chemical Society, doi: 10.1021/jacs.8b04848
DOI See at publisher website
Article 0 Reads 0 Citations The role of inter-species interactions in Salinispora specialized metabolism Nastassia V. Patin, Dimitrios J. Floros, Chambers C. Hughes,... Published: 01 July 2018
Microbiology, doi: 10.1099/mic.0.000679
DOI See at publisher website
Article 0 Reads 5 Citations Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality Gregory C. A. Amos, Takayoshi Awakawa, Robert N. Tuttle, Ann... Published: 11 December 2017
Proceedings of the National Academy of Sciences, doi: 10.1073/pnas.1714381115
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Genomics has revealed that even well-studied bacteria maintain many more biosynthetic gene clusters (BGCs) predicted to encode specialized metabolites than expected based on product discovery. These orphan BGCs are often assumed to be transcriptionally silent. Here, we show that a majority of the 46 BGCs observed in four strains of the marine actinomycete Salinispora are transcribed at levels that should facilitate product detection. In five cases, similar BGCs were differentially expressed among strains, suggesting that simple presence or absence analyses are not good predictors of metabolic output. Highly expressed BGCs were bioinformatically linked to their products, including a series of salinipostins not previously reported from Salinispora pacifica. Subsequent genetic experiments established a formal link between salinipostins and their cognate BGC.
Article 0 Reads 5 Citations Omics-based Natural Product Discovery and the Lexicon of Genome Mining Henrique Machado, Robert N. Tuttle, Paul R. Jensen Published: 23 November 2017
Current Opinion in Microbiology, doi: 10.1016/j.mib.2017.10.025
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Genome sequencing and the application of omic techniques are driving many important advances in the field of microbial natural products research. Despite these gains, there remain aspects of the natural product discovery pipeline where our knowledge remains poor. These include the extent to which biosynthetic gene clusters are transcriptionally active in native microbes, the temporal dynamics of transcription, translation, and natural product assembly, as well as the relationships between small molecule production and detection. Here we touch on a number of these concepts in the context of continuing efforts to unlock the natural product potential revealed in genome sequence data and discuss nomenclatural issues that warrant consideration as the field moves forward.
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