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Ferenc Hudecz  - - - 
Top co-authors See all
Eva Kiss

94 shared publications

Laboratory of Interfaces and Nanostructures, Institute of Chemistry, Eötvös Loránd University, 1117 Budapest, Hungary;(G.G.);(É.K.)

György Nagy

58 shared publications

10Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary

Anna Magyar

17 shared publications

Research Group of Peptide Chemistry, Department of Organic Chemistry, Hungarian Academy of Sciences, Eötvös Loránd University, 1117 Budapest, Hungary; and

Gergő Gyulai

15 shared publications

Laboratory of Interfaces and Nanostructures, Institute of Chemistry, Eötvös Loránd University, Budapest, Hungary

Gabriella Sármay

4 shared publications

Eötvös Loránd University

8
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Distribution of Articles published per year 
(2000 - 2018)
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Article 0 Reads 0 Citations Ferrocene-Containing Impiridone (ONC201) Hybrids: Synthesis, DFT Modelling, In Vitro Evaluation, and Structure–Activity ... Péter Bárány, Rita Szabó Oláh, Imre Kovács, Tamás Czuczi, Cs... Published: 03 September 2018
Molecules, doi: 10.3390/molecules23092248
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Inspired by the well-established clinical evidence about the interplay between apoptotic TRAIL (tumour necrosis factor-related apoptosis-inducing ligand) mechanism and reactive oxygen species (ROS)-mediated oxidative stress, a set of novel ONC201 hybrids containing the impiridone core and one or two differently positioned ferrocenylalkyl groups were synthesised in our present work. These two types of residues have been implicated in the aforementioned mechanisms associated with cytotoxic activity. A straightforward, primary amine-based synthetic approach was used allowing the introduction of a variety of N-substituents into the two opposite regions of the heterocyclic skeleton. Reference model compounds with benzyl and halogenated benzyl groups were also synthesised and tested. The in vitro assays of the novel impiridones on five malignant cell lines disclosed characteristic structure-activity relationship (SAR) featuring significant substituent-dependent activity and cell-selectivity. A possible contribution of ROS-mechanism to the cytotoxicity of the novel metallocenes was suggested by density functional theory (DFT)studies on simplified models. Accordingly, unlike the mono-ferrocenylalkyl-substituted products, the compounds containing two ferrocenylalkyl substituents in the opposite regions of the impiridone core display a much more pronounced long-term cytotoxic effect against A-2058 cell line than do the organic impiridones including ONC201 and ONC212. Furthermore, the prepared bis-metallocene derivatives also present substantial activity against COLO-205- and EBC-1 cell lines.
Article 0 Reads 1 Citation Affinity Purification and Comparative Biosensor Analysis of Citrulline-Peptide-Specific Antibodies in Rheumatoid Arthrit... Eszter Szarka, Petra Aradi, Krisztina Huber, Judit Pozsgay, ... Published: 22 January 2018
International Journal of Molecular Sciences, doi: 10.3390/ijms19010326
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Background: In rheumatoid arthritis (RA), anti-citrullinated protein/peptide antibodies (ACPAs) are responsible for disease onset and progression, however, our knowledge is limited on ligand binding affinities of autoantibodies with different citrulline-peptide specificity. Methods: Citrulline-peptide-specific ACPA IgGs were affinity purified and tested by ELISA. Binding affinities of ACPA IgGs and serum antibodies were compared by surface plasmon resonance (SPR) analysis. Bifunctional nanoparticles harboring a multi-epitope citrulline-peptide and a complement-activating peptide were used to induce selective depletion of ACPA-producing B cells. Results: KD values of affinity-purified ACPA IgGs varied between 10−6 and 10−8 M and inversely correlated with disease activity. Based on their cross-reaction with citrulline-peptides, we designed a novel multi-epitope peptide, containing Cit-Gly and Ala-Cit motifs in two–two copies, separated with a short, neutral spacer. This peptide detected antibodies in RA sera with 66% sensitivity and 98% specificity in ELISA and was recognized by 90% of RA sera, while none of the healthy samples in SPR. When coupled to nanoparticles, the multi-epitope peptide specifically targeted and depleted ACPA-producing B cells ex vivo. Conclusions: The unique multi-epitope peptide designed based on ACPA cross-reactivity might be suitable to develop better diagnostics and novel therapies for RA.
BOOK-CHAPTER 0 Reads 0 Citations Proteins and peptides for the immunodiagnosis and therapy of Mycobacterium tuberculosis infections Szilvia Bősze, Ferenc Hudecz Published: 04 November 2015
Amino Acids, Peptides and Proteins, doi: 10.1039/9781782622680-00146
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Article 0 Reads 9 Citations Role of N - or C -Terminal Biotinylation in Autoantibody Recognition of Citrullin Containing Filaggrin Epitope Peptides ... Fruzsina Babos, Anna Magyar, Ferenc Hudecz, Eszter Szarka, G... Published: 06 May 2013
Bioconjugate Chemistry, doi: 10.1021/bc400073z
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Article 0 Reads 7 Citations Structure, enzymatic stability and antitumor activity of sea lamprey GnRH-III and its dimer derivatives Gábor Mező, András Czajlik, Marilena Manea, Annamaria Jakab,... Published: 01 April 2007
Peptides, doi: 10.1016/j.peptides.2006.12.014
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Article 0 Reads 7 Citations Disulfide bond rearrangement during regioselective oxidation in PhS(O)Ph/CH3SiCl3 mixture for the synthesis of α-conotox... Ildikó Szabó, Gitta Schlosser, Ferenc Hudecz, Gábor Mezo Published: 01 January 2007
Biopolymers, doi: 10.1002/bip.20616
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