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José Antonio Bengoechea  - - - 
Top co-authors See all
Dennis H. Bamford

315 shared publications

Molecular and Integrative Biosciences Research Program, University of Helsinki, Viikinkaari 1, 00014, Helsinki, Finland

Oscar P. Kuipers

282 shared publications

Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands

Robert A. Burne

220 shared publications

Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida, USA

Laura J. V. Piddock

208 shared publications

Global Antibiotic Research & Development Partnership (GARDP), c/o Drugs for Neglected Diseases initiative, 15 Chemin Louis-Dunant, Geneva, Switzerland

James C. Paton

202 shared publications

Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, South Australia, Australia;(S.F.A.);(M.K.);(V.G.P.);(J.J.W.);(J.C.P.)

Publication Record
Distribution of Articles published per year 
(1999 - 2015)
Total number of journals
published in
Publications See all
Article 0 Reads 0 Citations 2-Hydroxylation of Acinetobacter baumannii Lipid A Contributes to Virulence Toby L. Bartholomew, Timothy J. Kidd, Joana Sá Pessoa, Raque... Published: 25 March 2019
Infection and Immunity, doi: 10.1128/IAI.00066-19
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Acinetobacter baumannii causes a wide range of nosocomial infections. This pathogen is considered a threat to human health due to the increasingly frequent isolation of multidrug-resistant strains.
Article 0 Reads 0 Citations Klebsiella pneumoniae infection biology: living to counteract host defences José A Bengoechea, Joana Sa Pessoa Published: 18 November 2018
FEMS Microbiology Reviews, doi: 10.1093/femsre/fuy043
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Klebsiella species cause a wide range of diseases including pneumonia, urinary tract infections (UTIs), bloodstream infections and sepsis. These infections are particularly a problem among neonates, elderly and immunocompromised individuals. Klebsiella is also responsible for a significant number of community-acquired infections. A defining feature of these infections is their morbidity and mortality, and the Klebsiella strains associated with them are considered hypervirulent. The increasing isolation of multidrug-resistant strains has significantly narrowed, or in some settings completely removed, the therapeutic options for the treatment of Klebsiella infections. Not surprisingly, this pathogen has then been singled out as an ‘urgent threat to human health’ by several organisations. This review summarises the tremendous progress that has been made to uncover the sophisticated immune evasion strategies of K. pneumoniae. The co-evolution of Klebsiella in response to the challenge of an activated immune has made Klebsiella a formidable pathogen exploiting stealth strategies and actively suppressing innate immune defences to overcome host responses to survive in the tissues. A better understanding of Klebsiella immune evasion strategies in the context of the host–pathogen interactions is pivotal to develop new therapeutics, which can be based on antagonising the anti-immune strategies of this pathogen.
Article 0 Reads 1 Citation Modulation of Haemophilus influenzae interaction with hydrophobic molecules by the VacJ/MlaA lipoprotein impacts strongl... Ariadna Fernández-Calvet, Irene Rodríguez-Arce, Goizeder Alm... Published: 02 May 2018
Scientific Reports, doi: 10.1038/s41598-018-25232-y
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Airway infection by nontypeable Haemophilus influenzae (NTHi) associates to chronic obstructive pulmonary disease (COPD) exacerbation and asthma neutrophilic airway inflammation. Lipids are key inflammatory mediators in these disease conditions and consequently, NTHi may encounter free fatty acids during airway persistence. However, molecular information on the interplay NTHi-free fatty acids is limited, and we lack evidence on the importance of such interaction to infection. Maintenance of the outer membrane lipid asymmetry may play an essential role in NTHi barrier function and interaction with hydrophobic molecules. VacJ/MlaA-MlaBCDEF prevents phospholipid accumulation at the bacterial surface, being the only system involved in maintaining membrane asymmetry identified in NTHi. We assessed the relationship among the NTHi VacJ/MlaA outer membrane lipoprotein, bacterial and exogenous fatty acids, and respiratory infection. The vacJ/mlaA gene inactivation increased NTHi fatty acid and phospholipid global content and fatty acyl specific species, which in turn increased bacterial susceptibility to hydrophobic antimicrobials, decreased NTHi epithelial infection, and increased clearance during pulmonary infection in mice with both normal lung function and emphysema, maybe related to their shared lung fatty acid profiles. Altogether, we provide evidence for VacJ/MlaA as a key bacterial factor modulating NTHi survival at the human airway upon exposure to hydrophobic molecules.
Article 0 Reads 2 Citations Vibrio cholerae amino acids go on the defense Jose A. Bengoechea Published: 22 December 2017
Journal of Biological Chemistry, doi: 10.1074/jbc.H117.000868
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Gram-negative bacteria remodel their surfaces to interact with the environment, particularly to protect pathogens from immune surveillance and host defenses. The enzyme AlmG is known to be involved in remodeling the Vibrio cholerae surface, but its specific role was not clear. A new study characterizes AlmG at the molecular level, showing it defies phylogenetic expectations to add amino acids to lipopolysaccharide (LPS). This LPS modification plays a pivotal role in V. cholerae resistance to antimicrobial peptides, weapons of the innate immune system against infections.
Article 0 Reads 4 Citations Natural killer cell-intrinsic type I IFN signaling controls Klebsiella pneumoniae growth during lung infection Masa Ivin, Amy Dumigan, Filipe N. De Vasconcelos, Florian Eb... Published: 07 November 2017
PLOS Pathogens, doi: 10.1371/journal.ppat.1006696
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Klebsiella pneumoniae is a significant cause of nosocomial pneumonia and an alarming pathogen owing to the recent isolation of multidrug resistant strains. Understanding of immune responses orchestrating K. pneumoniae clearance by the host is of utmost importance. Here we show that type I interferon (IFN) signaling protects against lung infection with K. pneumoniae by launching bacterial growth-controlling interactions between alveolar macrophages and natural killer (NK) cells. Type I IFNs are important but disparate and incompletely understood regulators of defense against bacterial infections. Type I IFN receptor 1 (Ifnar1)-deficient mice infected with K. pneumoniae failed to activate NK cell-derived IFN-γ production. IFN-γ was required for bactericidal action and the production of the NK cell response-amplifying IL-12 and CXCL10 by alveolar macrophages. Bacterial clearance and NK cell IFN-γ were rescued in Ifnar1-deficient hosts by Ifnar1-proficient NK cells. Consistently, type I IFN signaling in myeloid cells including alveolar macrophages, monocytes and neutrophils was dispensable for host defense and IFN-γ activation. The failure of Ifnar1-deficient hosts to initiate a defense-promoting crosstalk between alveolar macrophages and NK cell was circumvented by administration of exogenous IFN-γ which restored endogenous IFN-γ production and restricted bacterial growth. These data identify NK cell-intrinsic type I IFN signaling as essential driver of K. pneumoniae clearance, and reveal specific targets for future therapeutic exploitations.
Article 0 Reads 8 Citations Investigating intracellular persistence of Staphylococcus aureus within a murine alveolar macrophage cell line Alicia Lacoma, V. Cano, D. Moranta, V. Regueiro, D. Domíngue... Published: 12 September 2017
Virulence, doi: 10.1080/21505594.2017.1361089
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Objective: Staphylococcus aureus is a particularly difficult pathogen to eradicate from the respiratory tract. Previous studies have highlighted the intracellular capacity of S.aureus in several phagocytic and non-phagocytic cells. The aim of this study was to define S.aureus interaction within a murine alveolar macrophage cell line.