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Bernd Kammerer  - - - 
Top co-authors See all
Manfred Jung

168 shared publications

Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104 Freiburg, Germany

Stefan Günther

25 shared publications

Institute of Pharmaceutical SciencesAlbert-Ludwigs-Universität Freiburg Hermann-Herder-Str. 9 79104 Freiburg Germany

Steffen U. Eisenhardt

23 shared publications

Universitätsklinikum Freiburg, Klinik für Plastische und Handchirurgie

Elmar Stickeler

15 shared publications

German Cancer Consortium (DKTK), Heidelberg, Germany

Hans Neubauer

15 shared publications

University of Düsseldorf, Department of Obstetrics and Gynecology, Düsseldorf, Germany

7
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23
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Publication Record
Distribution of Articles published per year 
(2014 - 2017)
Total number of journals
published in
 
7
 
Publications See all
Conference 21 Reads 0 Citations Mitochondrial metabolomics reveals compartment-specific metabolic responses in yeast cells Daqiang Pan, Caroline Lindau, Simon Lagies, Stefan Günther, ... Published: 20 November 2017
The 2nd International Electronic Conference on Metabolomics, doi: 10.3390/iecm-2-04981
DOI See at publisher website
Article 0 Reads 2 Citations Metabolic Response to XD14 Treatment in Human Breast Cancer Cell Line MCF-7 Daqiang Pan, Michel Kather, Lucas Willmann, Manuel Schlimper... Published: 24 October 2016
International Journal of Molecular Sciences, doi: 10.3390/ijms17101772
DOI See at publisher website ABS Show/hide abstract
XD14 is a 4-acyl pyrrole derivative, which was discovered by a high-throughput virtual screening experiment. XD14 inhibits bromodomain and extra-terminal domain (BET) proteins (BRD2, BRD3, BRD4 and BRDT) and consequently suppresses cell proliferation. In this study, metabolic profiling reveals the molecular effects in the human breast cancer cell line MCF-7 (Michigan Cancer Foundation-7) treated by XD14. A three-day time series experiment with two concentrations of XD14 was performed. Gas chromatography-mass spectrometry (GC-MS) was applied for untargeted profiling of treated and non-treated MCF-7 cells. The gained data sets were evaluated by several statistical methods: analysis of variance (ANOVA), clustering analysis, principle component analysis (PCA), and partial least squares discriminant analysis (PLS-DA). Cell proliferation was strongly inhibited by treatment with 50 µM XD14. Samples could be discriminated by time and XD14 concentration using PLS-DA. From the 117 identified metabolites, 67 were significantly altered after XD14 treatment. These metabolites include amino acids, fatty acids, Krebs cycle and glycolysis intermediates, as well as compounds of purine and pyrimidine metabolism. This massive intervention in energy metabolism and the lack of available nucleotides could explain the decreased proliferation rate of the cancer cells.
Article 3 Reads 6 Citations Alterations of the exo- and endometabolite profiles in breast cancer cell lines: A mass spectrometry-based metabolomics ... Lucas Willmann, Manuel Schlimpert, Marc Hirschfeld, Thalia E... Published: 01 June 2016
Analytica Chimica Acta, doi: 10.1016/j.aca.2016.04.047
DOI See at publisher website PubMed View at PubMed
Article 0 Reads 10 Citations Metabolic profiling of breast cancer: Differences in central metabolism between subtypes of breast cancer cell lines Lucas Willmann, Manuel Schlimpert, Sebastian Halbach, Thalia... Published: 01 September 2015
Journal of Chromatography B, doi: 10.1016/j.jchromb.2015.07.021
DOI See at publisher website PubMed View at PubMed
Article 2 Reads 4 Citations Metabolome analysis via comprehensive two-dimensional liquid chromatography: identification of modified nucleosides from... Lucas Willmann, Thalia Erbes, Sonja Krieger, Jens Trafkowski... Published: 04 March 2015
Analytical and Bioanalytical Chemistry, doi: 10.1007/s00216-015-8516-6
DOI See at publisher website PubMed View at PubMed
Article 1 Read 2 Citations Metabolic pathway monitoring of phenalinolactone biosynthesis from Streptomyces sp. Tü6071 by liquid chromatography/mass... Christiane Kiske, Anika Erxleben, Xavier Lucas, Lucas Willma... Published: 22 May 2014
Rapid Communications in Mass Spectrometry, doi: 10.1002/rcm.6920
DOI See at publisher website PubMed View at PubMed
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