My initial research interests focused on the antibody response elicited during the Herpes Simplex Virus (HSV) infection and the protection conferred in vivo by human monoclonal antibodies. Then, I worked on the synergy evaluation of anti-herpetic compounds acting on different steps of the virus life cycle, on the characterization of sera from HSV infected subjects, and on modeling HSV reactivation dynamics in a patterned human neuron-to-keratinocyte circuit reconstituted in a microfluidic device. In the last two years I focused my work on SARS-CoV-2 infection: starting from the isolation of the different viral variants of interest (VOCs) and NGS sequencing for epidemiologic surveillance, I dedicated to the characterization of entry mechanisms exploited by the virus, the evaluation of antiviral drugs against the infection, and the dissection of the immune response of COVID-19 patients and vaccinated subjects.
Research Keywords & Expertise
Microbiology
Monoclonal Antibodies
Virology
herpes simplex virus
antibody responses
bacteriophage
Antibody engineering
SARS- CoV-2
Fingerprints
SARS- CoV-2
Monoclonal Antibodies
herpes simplex virus
antibody responses
bacteriophage
Virology
Short Biography
My initial research interests focused on the antibody response elicited during the Herpes Simplex Virus (HSV) infection and the protection conferred in vivo by human monoclonal antibodies. Then, I worked on the synergy evaluation of anti-herpetic compounds acting on different steps of the virus life cycle, on the characterization of sera from HSV infected subjects, and on modeling HSV reactivation dynamics in a patterned human neuron-to-keratinocyte circuit reconstituted in a microfluidic device. In the last two years I focused my work on SARS-CoV-2 infection: starting from the isolation of the different viral variants of interest (VOCs) and NGS sequencing for epidemiologic surveillance, I dedicated to the characterization of entry mechanisms exploited by the virus, the evaluation of antiviral drugs against the infection, and the dissection of the immune response of COVID-19 patients and vaccinated subjects.
