5th International Electronic Conference on Medicinal Chemistry

drug discovery and development

Welcome from the Chair

Proud of the success of the previous editions, it is our pleasure to invite you to contribute to the 5^th International Electronic Conference on Medicinal Chemistry. The Conference, organized and sponsored by the peer-reviewed journal Pharmaceuticals, will be held online during the month of November 2019.

The aim of the Conference is to gather researchers from all over the world and encourage discussions on any scientific field related to drug discovery and development. Posting presentations, videos, or posters disclosing your recent outstanding results enables you to take advantage of the conference to promote your work among thousands of your peers. Participation, as an author or a visitor, is ABSOLUTELY FREE; simply register on the home page.

This year, as the conference sponsor, Pharmaceuticals will be giving an award for the Best Presentation as elected by the scientific committee, which consists of 500 Swiss Francs. We hope you will be able to join this exciting event and enjoy a stimulating exchange with your peers around the world. Also, we will launch a Special Issue covering the event.

On behalf of our dynamic editorial staff and active scientific committee, we warmly invite you to join us during this fifth edition and we look forward to posting your contributions.

Call for Papers

The members of the scientific committee are pleased to announce the Call for Papers for the 5th International Electronic Conference on Medicinal Chemistry and to invite each researcher working in that exciting field of science to share his/her recent results with his/her colleagues around the world.

The conference will cover a wide range of aspects involved in drug discovery and development. A non exhaustive list of topics that will be considered comprises:

ADMET
Animal experimentation
Assay development
Biomarkers
Biomolecules
Biosensors
Biotechnology
Chemical synthesis
Clinical studies and side effects reports
Combinatorial chemistry
Drug delivery (including bioconjugates and prodrugs)
High throughput screening
Hit identification
Imaging techniques
In silico experiments
In vitro studies
Lead optimization
Omics
Pharmaceutical analysis
Scale-up
Structure–activity relationships
Target selection

Participation at the 5th International Electronic Conference on Medicinal Chemistry is absolutely free of charge for contributors and visitors. Researchers are invited to provide a short abstract on line at https://www.sciforum.net/login from now until October 25, 2019. Acceptance will be notified within a week after submission of the abstract. Then the author(s) will be asked to present their work (in English) in the form of a slide show (or a video) using the template provided by the conference (see Instructions for Authors). Posters, realized following the template provided online, will also be considered. All accepted submissions will be displayed online, at https://sciforum.net/conference/ECMC2019, on November 1-30, 2019.

Authors of the most outstanding contributions, as selected by the Scientific Committee, will be invited to publish their work as a research article free of charge or at a discounted price, in a Special Issue of the journal Pharmaceuticals.

The Scientific Committee looks forward to receiving contributions in response to this call and will be glad to provide any further information to interested parties. Questions may be addressed to the chairman via e-mail at jean-jacques.vandeneynde@ex.umons.ac.be or to the Pharmaceuticals editorial office at ecmc@mdpi.com.

We thank you in advance for your attendance of this conference and look forward to a stimulating exchange.

Conference Organizers

MDPI-Pharmaceuticals

MDPI

Conference Chairs

Dr. Jean Jacques Vanden Eynde

Formerly head of the Department of Organic Chemistry (FS), University of Mons-UMONS, 7000 Mons, Belgium Website

Conference Committee

Dr. Alfredo Berzal-Herranz

Department of Molecular Biology, Instituto de Parasitología y Biomedicina López-Neyra, (IPBLN-CSIC), PTS Granada, Av del Conocimiento 17, 18016 Granada, Spain

Dr. Conor R. Caffrey

Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA

Prof. Dr. Valentina Onnis

Department of Life and Environmental Sciences, Unit of Pharmaceutical, Pharmacological and Nutraceutical Sciences Via Ospedale 72, I-09124 Cagliari, Italy

Prof. Dr. Andrea Porcheddu

Università degli Studi di Cagliari, Dipartimento di Scienze Chimiche e Geologiche, Cittadella Universitaria, SS 554, bivio per Sestu, 09042, Monserrato (CA), Italy

Prof. Dr. Maria Emília De Sousa

Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências, Químicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira 228, 4050-313, Porto, Portugal,
Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Universidade do Porto, Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, S/N 4450-208 Matosinhos, Portugal

Dr. Annie Mayence

Formerly professor at the Haute Ecole Provinciale de Hainaut-Condorcet, 7330 Saint-Ghislain, Belgium

Dr. Maria M. M. Santos

Faculty of Pharmacy, Universidade de Lisboa, Avenida Professor Gama Pinto, 1649-003 Lisboa, Portugal

Prof. Dr. Atanas G. Atanasov

Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, 05-552 Jastrzebiec, Poland,
Department of Pharmacognosy, University of Vienna, Austria,
International Natural Product Sciences Taskforce (INPST)

Keynote Speakers

Prof. Dr. Leonidas A. Phylactou

Chief Executive Medical Director, The Cyprus Institute of Neurology & Genetics, PO Box 23462, 1683 Nicosia, Cyprus

Dr. Simone Lucarini

Assistant Professor at the Department of Biomolecular Sciences, Section of Chemistry, School of Pharmacy, University of Urbino, Italy

Dr. Claudio Ferrante

Università degli Studi G. d'Annunzio Chieti e Pescara | UNICH · Department of Pharmacy

Dr. Giustino Orlando

University of G. d'Annunzio Chieti and Pescara, Chieti, Italy

Dr. Mariia Nesterkina

Odessa National Polytechnic University, Odessa, Ukraine

Prof. Dr. Maria Emília De Sousa

Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências, Químicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira 228, 4050-313, Porto, Portugal, Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Universidade do Porto, Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Mato

Dr. Maria M. M. Santos

Faculty of Pharmacy, Universidade de Lisboa, Avenida Professor Gama Pinto, 1649-003 Lisboa, Portugal

Dr. Maurício Homem-de-Mello

Universidade de Brasília, Brasilia, Brazil

Dr. Alfredo Berzal-Herranz

Department of Molecular Biology, Instituto de Parasitología y Biomedicina López-Neyra, (IPBLN-CSIC), PTS Granada, Av del Conocimiento 17, 18016 Granada, Spain

Dr. Ievgeniia Iermak

University of São Paulo

Mr. Christos Tsagkaris

University of Crete

Dr. Šárka Pospíšilová

Regional Centre of Advanced Technologies and Materials (RCPTM), Palacký University

Ms. Cristina Almeida

University of Porto

Dr. Patrícia Rijo

Universidade Lusófona de Humanidades e Tecnologias, Lisbon, Portugal

Ms. Eduarda Fernandes

University of Minho

Dr. Edeildo Ferreira da Silva-Júnior

Federal University of Alagoas

Keynote Presentations

Sessions

A. ECMC-5
B. Posters
C. keynote Presentation

List of accepted submissions (113)

Id	Title	Authors	Presentation Video
sciforum-026644	*Preliminary phytochemical analysis and in vitro* anti-cancer screening of ethanolic extract of roots of Bauhinia tomentosa L.against HUH-7 human liver cancer cell lines** Ramaiah Maddi Submitted: 23 Jul 2019 Abstract: Show Abstract	Ramaiah Maddi	N/A	Show Abstract
The most effective way to reduce the worldwide burden of liver cancer is to prevent it from happening in the first place. The current treatment of liver cancer has significant side effects. Hence, there is a need to develop anti-liver cancer agents of plant origin, which are less toxic, more efficacious and cost-effective. The present study has been performed experimentally by in vitro to examine the anti-liver cancer activity of roots of Bauhinia tomentosa L (Fabaceae). The roots of B. tomentosa was tested for its anti-cancer activity against HUH-7 human liver cancer cell lines by MTT assay. The standard used in this assay was Camptothecin (CPT) at 25µG concentration. Plant extract was tested at 25μg/mL, 50 μg/mL,100μg/mL, 200 μg/mL and 400 μg/mL concentrations. The percent cell viability of standard drug was found to be 49.59% and plant extracts at 25 μg/mL, 50 μg/mL,100 μg/mL, 200 μg/mL and 400 μg/mL concentrations were found to be 93.82%, 86.21%, 74.48%, 63.04%, 45.71% respectively. The cell morphology was observed and recorded under a microscope. The results clearly indicated that B. tomentosa shows a dose-dependent activity and it was maximum at 400μg/mL concentration where it shows 45.71% of liver cancer cell viability and it was comparable to the standard drug where it shows 49.59% of viability.
sciforum-026659	*Effect of administration of aqueous extracts of Securidaca longepedunculata* stem barks on enzymes of the small intestine alloxan-induced diabetic rats** Oluwaferanmi Adefolaju , Julius Arannilewa , Ayokanmi Olowo Submitted: 25 Jul 2019 Abstract: Show Abstract	Oluwaferanmi Adefolaju , Julius Arannilewa , Ayokanmi Olowo	N/A	Show Abstract
ABSTRACT The stem barks of Securidaca longepedunculata are used traditionally across Africa for the treatment of diabetes, cancer, metabolic diseases and asthma. This study was aimed at investigating the potential enzyme activities of the S. longepedunculata on the small intestine. Aqueous extracts of S. longepedunculata were tested in vivo on animal models: A total of 12 Wister rats were assigned into four (I–IV) groups of three animals each. Group I served as the control and was administered 0.5mL of distilled water. Groups II–IV were given 0.5, 1 and 2mg/kg body weight of S. longepedunculata stem bark extracts. The activities of the following enzymes, Alanine transaminase (ALT), Lactate dehydrogenase (LDH), Alkaline phosphatase (ALP), Aspartate transaminase (AST), were assayed in the small intestine. The result revealed a significant reduction in ALP and LDH. This gives an indication that the administration of aqueous extract of securidaca longepedunculata can elicit detrimental effect in the small intestine of the albino rat. Also the result obtained in the qualitative analysis shows the presence of phytochemicals such as: saponin, flavonoid and terpernoid.
sciforum-026688	*Screening for PKS-I gene cluster from endophytic actinomycetes residing in Ocmium tenuiflorum* (Tulsi) and Azadirachta indica (Neem)** Asma Ilyas , Rabia Tanvir , Ali Ahmad Sheikh , Wasim Shehzad Submitted: 29 Jul 2019 Abstract: Show Abstract	Asma Ilyas , Rabia Tanvir , Ali Ahmad Sheikh , Wasim Shehzad	N/A	Show Abstract
Polyketide synthases type I (PKS-I) gene cluster is responsible for the synthesis of highly assorted group of secondary metabolites such as antimicrobial and anticancer agents. In our study, screening was carried out using degenerate primers to determine the presence of PKS-I gene cluster in endophytic actinomycetes isolated from two medicinal plants Ocmium teniflorum (Tulsi) and Azadirachta indica (Neem). A total of 28 endophytes that were isolated and identified from our previous study were further confirmed through 16S rRNA gene sequencing to exhibit a 99% similarity with Streptomyces sp. The molecular screening using PCR revealed the presence of PKS- I gene with a product size of 750bps in the isolates, FHK-1, FHK-2, FHK-3, FHK-4, FHK-5, FHK-6, FHK-7, FHK-8, FHK-9, FHK-11, FHK-13, FHK-16, FHK-18, FHK-20, FHK-21, FHK-23, FHK,25 and FHK-28. These isolates were further checked for their antimicrobial potential using their crude extracts. They displayed prominent bioactivity against ATCC pathogens, Escherichia coli, Proteus vulgaris, Rhodococcus equi, Staphylococcus epidermidis, Enterococcus faecalis, and Acinetobacter baumanii. Our study revealed that the endophytes from O. tenuiflorum and A. indica are bioactive and versatile harboring the PKS-I gene cluster.
sciforum-026789	*Phytochemicals and in vitro* antioxidant studies of Daucus carota L. seed extracts** Habibu Tijjani , Abubakar Mohammed , Adegbenro Adegunloye Submitted: 21 Aug 2019 Abstract: Show Abstract	Habibu Tijjani , Abubakar Mohammed , Adegbenro Adegunloye	N/A	Show Abstract
Daucus carota seeds are important in the treatment of a broad spectrum of ailments. This study evaluated the phytochemicals status and in vitro antioxidant effects of aqueous and diethyl ether extracts of D. carota seed. 50 g of D. carota seeds were pulverized and dissolved in 200 ml distilled water for 24 hours, the crude aqueous extract obtained (AQE, 11.05g, 22.1% yield) was partition in water/diethyl ether (2:1) to yield the diethyl ether fraction (DEE, 0.45g, 0.90% yield). The extracts were evaluated for quantitative phytochemicals, 2,2-diphenyl-1-picrylhydrazyl (DPPH), total antioxidant capacity and ferric ion reducing effect at 0.4 to 2.0 mg/ml. AQE and DEE contain alkaloids (7.28%, 5.22%), flavonoids (5.56%, 4.03%), saponins (4.68%, 1.52%), steroids (3.23%, 2.71%), tannins (0.40%, 0.27%) and phenol (0.37%, 0.22%) respectively. The DPPH scavenging effect of the extracts was superior to the reference compound butylated hydroxytolune (BHT) with IC₅₀ of 2.84 mg/ml compared to AQE with 2.00 mg/ml and DEE with 1.39 mg/ml respectively. AQE extract when compared with BHT had similar total antioxidant capacity while BHT was significantly (p<0.05) higher than DEE. However, both AQE and DEE express better ferric ion reducing effect compared to BHT at the concentrations range. The results shows that aqueous and diethyl ether extracts of D. carota seed possess good in vitro radical scavenging activities with presence of higher phytochemical content in the aqueous extract.
sciforum-026816	Medicated surgical braces Dharmik Mehta Submitted: 27 Aug 2019 Abstract: Show Abstract	Dharmik Mehta	N/A	Show Abstract
In current scenario, several surgical braces are available for different body parts like knee, elbow, back etc. for several clinical conditions, especially pain in that part of the body. All these supportive treatments are aided by some medication through oral route, which produces several side effects on prolonged use. Present work endeavors to combine these different treatments: supportive and medicated treatments by incorporating sustained release medicated topical patch into the inner side of surgical braces through specially designed patch holder mechanism for easy incorporation and removal of patch. It not only eliminates need of oral medication but also gives localized administration of medication, thus resulting in more patient compliant treatment with improving overall safety profile. For developing model prototype of the same, combination of surgical knee brace and oral NSAID (diclofenac) was selected. In order to execute the working prototype, a pocket mechanism to incorporate a sustained release patch of 7 cm X 7 cm size was designed. Patch formulation was randomly selected based on trial batches for sustaining drug release up to 12 h, considering put on- put off phases of brace of 12 h each. The pocket was designed in such a way that in case of any discomfort or other unfavorable conditions, it can be easily removed from the brace. Flexibility in terms of size, shape and drug release profiles proves its versatility for other supportive braces and medications. Thus this innovation can be easily extended for other braces like elbow braces, shoulder braces, back braces etc. It not only enhances efficacy of the current treatments but also improves patient compliance significantly.

Full List

List of Authors (453)

Ranjana .

Jorge A. R. Salvador

Emad Abdallah

Mohammed S. M. Abdelbaky

Olufunso Abosede

Artur Adamczak

Oluwaferanmi Adefolaju

António Aguiar

Joana Almeida

Basam Alzoubi

Roberto Amílcar

Nurul Suhaili Amirah Mamat

Claire Andréjak

Margarida Duarte Araújo

João Araújo-Júnior

Liubov Artiukh

Darko Ašanin

Instructions for Authors

Instructions for Authors

Submissions should be done by the authors online by registering with www.sciforum.net, and using the "Start New Submission" function once logged into system.

Researchers interested in attending the conference must submit, on this website and not later than 25 October 2019, an abstract of the work they intend to present.

After the abstract is accepted by the Scientific Committee (1-5 days after receipt of the abstract), the authors will be invited to prepare a full description of their work preferably under the form of a PowerPoint presentation, and to upload it before 30 October 2019 to ensure final check.

The presentations will be accessible on https://sciforum.net/conference/ECMC2019 during the time of the conference.

Authors are encouraged to prepare a presentation using the template provided by the Conference. Slides will be displayed directly in the website using Sciforum.net's proprietary slides viewer. They can be prepared in exactly the same way as for any traditional conference where research results can be presented. Slides should be converted to the PDF format before submission so that our process can easily and automatically convert them for online displaying.

The following organization is recommended for your presentation:

Length of the presentation: no more than 30 slides
Slide 1 (strictly one slide): Title, Authors’ names, Affiliation(s), email address of the corresponding Author, and, not mandatory, logos of the laboratory and/or institution;
Slide 2 (strictly one slide): Graphical Abstract, repeat the title of the presentation but avoid other text as far as possible;
Slide 3 (strictly one slide): Abstract (max 200 words) and 3-5 keywords separated by semicolons;
Slide 4 and following slides: should contain (in the given sequence) Introduction, Results and Discussion; Conclusions.
Last slide: Acknowledgments and, not mandatory, logos of sponsors of the work.

Authors can also submit their work under the form of a poster by using the template provided by the Conference. Notice that posters will not be evaluated for the travel award.

2.ecmc-5_ecmc-5_Poster_template.pptx
1.Electronic_Conference_on_Medicinal_Chemistry_PPT_template_file.pptx

Event Awards

Pharmaceuticals and the Organizing Committee of ECMC-5 gladly announce the winners of the ECMC-5 Best Presentation Award, Keynote Speaker Award, and Best Poster Award in 2019.

Best Presentation Award - " Novel radiolabeled silicon rhodamine dyes for bimodal scintigraphic and optical imaging " (Authors: Thines Kanagasundaram *, Carsten Sven Kramer, Eszter Boros, Klaus Kopka)

"Thines Kanagasundaram studied chemistry at the Ruprecht-Karls University in Heidelberg, Germany and received his Master’s degree in 2017. Currently he is a second year Ph.D. student in the German Cancer Research Center (Research Field: Radiopharmaceutical Chemistry, supervisor: Prof. Klaus Kopka) in Heidelberg. His doctoral thesis is focused on the synthesis of novel radiolabeled organic fluorophores for bimodal scintigraphic- and optical imaging which are of clinical interest for precise fluorescence-guided resection of tumors and their lymph node metastases."

Keynote Speaker Award - " Design, synthesis and in vitro biological evaluation of acrylamide derivatives against Chikungunya virus " (Authors: Edeildo Ferreira da Silva-Júnior *, Gabriel Felipe Silva Passos, Matheus Gabriel Moura Gomes, Thiago Mendonça de Aquino, Stephannie Janaina Maia de Souza, João Pedro Monteiro Cavalcante, Elane Conceição dos Santos, Ênio José Bassi, João Xavier de Araújo-Júnior)

" Edeildo Ferreira da Silva-Júnior studied Pharmacy at the Federal University of Alagoas, Maceió – Brazil. Subsequently, he received his Master’s degree in Pharmaceutical Sciences by the Federal University of Alagoas, Brazil, as well. Since his Master degree, he is working in the medicinal chemistry of Neglected Tropical Diseases (NTD’s), collecting valuable experiences on the researches addressed to the development of novel synthetic compounds with activity against Leishmania spp. and Trypanosoma cruzi, in association with collaborators from the University of Strasbourg – France. He has Ph.D. degree in Chemistry and Biotechnology, with focus on the Medicinal and Biological Chemistry, obtained at the Federal University of Alagoas. During his Ph.D., he developed part of his project and thesis at the Institute of Pharmacy and Biochemistry from the Johannes Gutenberg University of Mainz, Germany. Current, he is Professor at the Chemistry and Biotechnology Institute from the Federal University of Alagoas, where he acts as Project-Leader and Laboratory-Head. Furthermore, he develops projects involving collaborators from the Johannes Gutenberg University of Mainz and Würtzburg University (Germany). He has several patents and high-qualified publications in organic and medicinal chemistry fields, such as Bioorganic Chemistry, Molecules, Current Topics in Medicinal Chemistry, Biosensors & Bioelectronics, Bioorganic & Medicinal Chemistry, Current Drug Metabolism, Biomedicine & Pharmacotherapy, and others. "

Best Poster Award - " Biological evaluation of Cetrarioid clade as cholinesterase inhibitors" (Authors: Noelia Fraga Matías, Isabel Maria Ureña Vacas, Elena González-Burgos *, M. Pilar Gómez-Serranillos)

" Noelia Fraga Matías is a collaboration scholarship student, Isabel Ureña Vacas is a second-year PhD student, Dr. Elena González Burgos is Assistant Professor and Dr. M. Pilar Gómez-Serranillos is Professor and Director of the research group. They belong to the Research Group Pharmacology of Natural Products of the Department of Pharmacology, Pharmacognosy and Botany of the Faculty of Pharmacy of the University Complutense of Madrid (Spain). Our consolidated research group has a long history studying phytochemical constituents and pharmacological activities of natural products. Particularly, one of our research lines, is to evaluate the neuroprotective activity of natural products from medicinal plants and lichens, deepening our understanding of its mechanisms of action. In parallel, we evaluate the ability of these natural compounds to cross the blood-brain barrier."

The Awards

Best Presentation Award

Number of Awards Available: 1

This year, as a sponsor, Pharmaceuticals would like to award the best presentation as elected by the members of the scientific committee. The Award will consist of 500 Swiss Francs. We look forward to posting your contributions.

Keynote Speaker Award

Number of Awards Available: 1

This year, as a sponsor, Pharmaceuticals would like to award the best Keynote Speaker as elected by the members of the scientific committee. The Award will consist of 300 Swiss Francs. We look forward to your contributions.

Best Poster Award

Number of Awards Available: 1

This year, as a sponsor, Pharmaceuticals would like to award the best poster as elected by the members of the scientific committee. The Award will consist of 200 Swiss Francs. We look forward to your contributions.

Terms and Conditions:

Criteria

1. Full PPT presentation must be submitted to ECMC-5.
2. The quality of the presentation.
3. The scientific content of the presentation

Evaluation

1. Each Evaluation Committee member will give an assessment for each applicant in terms of the criteria outlined above.
2. Total score for each presentation will be ranked, from highest to lowest.
3. If two or more students get the same score, further evaluation will be carried out.
4. All decisions made by the Evaluation Committee are final.

Sponsors and Partners

Organizers

Media Partners

Exhibition Hall

Copyright

MDPI, the publisher of the Sciforum.net platform, is an open access publisher. We believe that authors should retain the copyright to their research works. Hence, by submitting a contribution to this conference, the authors retain the copyright of their contribution, but they grant MDPI AG the non-exclusive right to publish this contribution online on the Sciforum.net platform. This means the authors can easily submit their contribution to any scientific journal at a later stage and transfer the copyright to its publisher (if required by that publisher).

5th International Electronic Conference on Medicinal Chemistry

1–30 Nov 2019

Welcome from the Chair

Call for Papers

Conference Organizers

Conference Chairs

Conference Committee

Keynote Speakers

Keynote Presentations

Sessions

List of accepted submissions (113)

List of Authors (453)

Instructions for Authors

Event Awards

The Awards

Terms and Conditions:

Sponsors and Partners

Organizers

Media Partners

Exhibition Hall

Copyright

A. ECMC-5

Submissions

B. Posters

Submissions

C. keynote Presentation

Submissions