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5th International Electronic Conference on Medicinal Chemistry

01/11/2019 - 30/11/2019

drug discovery and development
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Welcome from the Chair

Proud of the success of the previous editions, it is our pleasure to invite you to contribute to the 5th International Electronic Conference on Medicinal Chemistry. The Conference, organized and sponsored by the peer-reviewed journal Pharmaceuticals, will be held online during the month of November 2019.

The aim of the Conference is to gather researchers from all over the world and encourage discussions on any scientific field related to drug discovery and development. Posting presentations, videos, or posters disclosing your recent outstanding results enables you to take advantage of the conference to promote your work among thousands of your peers. Participation, as an author or a visitor, is ABSOLUTELY FREE; simply register on the home page.

This year, as the conference sponsor, Pharmaceuticals will be giving an award for the Best Presentation as elected by the scientific committee, which consists of 500 Swiss Francs. We hope you will be able to join this exciting event and enjoy a stimulating exchange with your peers around the world. Also, we will launch a Special Issue covering the event.

On behalf of our dynamic editorial staff and active scientific committee, we warmly invite you to join us during this fifth edition and we look forward to posting your contributions.

Call for Papers

The members of the scientific committee are pleased to announce the Call for Papers for the 5th International Electronic Conference on Medicinal Chemistry and to invite each researcher working in that exciting field of science to share his/her recent results with his/her colleagues around the world.

The conference will cover a wide range of aspects involved in drug discovery and development. A non exhaustive list of topics that will be considered comprises:

  • ADMET
  • Animal experimentation
  • Assay development
  • Biomarkers
  • Biomolecules
  • Biosensors
  • Biotechnology
  • Chemical synthesis
  • Clinical studies and side effects reports
  • Combinatorial chemistry
  • Drug delivery (including bioconjugates and prodrugs)
  • High throughput screening
  • Hit identification
  • Imaging techniques
  • In silico experiments
  • In vitro studies
  • Lead optimization
  • Omics
  • Pharmaceutical analysis
  • Scale-up
  • Structure–activity relationships
  • Target selection

Participation at the 5th International Electronic Conference on Medicinal Chemistry is absolutely free of charge for contributors and visitors. Researchers are invited to provide a short abstract on line at http://www.sciforum.net/login from now until October 25, 2019. Acceptance will be notified within a week after submission of the abstract. Then the author(s) will be asked to present their work (in English) in the form of a slide show (or a video) using the template provided by the conference (see Instructions for Authors). Posters, realized following the template provided online, will also be considered. All accepted submissions will be displayed online, at https://sciforum.net/conference/ECMC2019, on November 1-30, 2019.

Authors of the most outstanding contributions, as selected by the Scientific Committee, will be invited to publish their work as a research article free of charge or at a discounted price, in a Special Issue of the journal Pharmaceuticals.

The Scientific Committee looks forward to receiving contributions in response to this call and will be glad to provide any further information to interested parties. Questions may be addressed to the chairman via e-mail at [email protected] or to the Pharmaceuticals editorial office at [email protected].

We thank you in advance for your attendance of this conference and look forward to a stimulating exchange.



Conference Organizers

MDPI-Pharmaceuticals

MDPI

DETAILS

Pharmaceuticals (ISSN 1424-8247) is an international scientific journal of medicinal chemistry and related drug sciences.

Introduction

Pharmaceuticals (ISSN 1424-8247) is an international scientific journal of medicinal chemistry and related drug sciences.

Conference Chairs

Dr. Jean Jacques Vanden Eynde

Formerly head of the Department of Organic Chemistry (FS), University of Mons-UMONS, 7000 Mons, Belgium Website

DETAILS

Editor-in-Chief of Pharmaceuticals, Former Head of the Department of Organic Chemistry, University of Mons-UMONS, Belgium

Bio
Editor-in-Chief of Pharmaceuticals, Former Head of the Department of Organic Chemistry, University of Mons-UMONS, Belgium

Conference Committee

Dr. Alfredo Berzal-Herranz

Department of Molecular Biology, Instituto de Parasitología y Biomedicina López-Neyra, (IPBLN-CSIC), PTS Granada, Av del Conocimiento 17, 18016 Granada, Spain

DETAILS

Dr. Conor R. Caffrey

Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA

DETAILS

Prof. Dr. Valentina Onnis

Department of Life and Environmental Sciences, Unit of Pharmaceutical, Pharmacological and Nutraceutical Sciences Via Ospedale 72, I-09124 Cagliari, Italy

DETAILS

Prof. Dr. Andrea Porcheddu

Università degli Studi di Cagliari, Dipartimento di Scienze Chimiche e Geologiche, Cittadella Universitaria, SS 554, bivio per Sestu, 09042, Monserrato (CA), Italy

DETAILS

Prof. Dr. Maria Emília De Sousa

Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências, Químicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira 228, 4050-313, Porto, Portugal,
Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Universidade do Porto, Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, S/N 4450-208 Matosinhos, Portugal

DETAILS

Dr. Annie Mayence

Formerly professor at the Haute Ecole Provinciale de Hainaut-Condorcet, 7330 Saint-Ghislain, Belgium

DETAILS

Dr. Maria M. M. Santos

Faculty of Pharmacy, Universidade de Lisboa, Avenida Professor Gama Pinto, 1649-003 Lisboa, Portugal

DETAILS

Prof. Dr. Atanas G. Atanasov

Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, 05-552 Jastrzebiec, Poland,
Department of Pharmacognosy, University of Vienna, Austria,
International Natural Product Sciences Taskforce (INPST)

DETAILS

Keynote Speakers

Prof. Dr. Leonidas A. Phylactou

Chief Executive Medical Director, The Cyprus Institute of Neurology & Genetics, PO Box 23462, 1683 Nicosia, Cyprus

DETAILS

Use of Aptamers to Deliver Therapeutic Genetic Sequences in Muscle

Leonidas Phylactou was born in Paphos, Cyprus on 2nd January 1970. He studied Medical Biochemistry at the University of Birmingham in the UK and then did a PhD in Molecular Genetics and Gene Therapy in the same University, although most of the time was spent at the University of Connecticut Health Centre in the USA. He then moved back to the UK, to the University of Oxford as a post-doctoral scientist, where he set up a team working on gene therapy for Myotonic Dystrophy. In 1998 he established a research group at the Cyprus Institute of Neurology and Genetics working on the gene function and gene therapy. In 2005 he was appointed Head of the Department of Molecular Genetics, Function and Therapy in which, apart from the research activities, he is responsible for diagnostic services in Medical Genetics. His research interests focus on the gene therapy for muscular dystrophy, the identification of biomarkers in Myotonic Dystrophy and the investigation of molecular causes for inherited diseases. Since November 2015 he is the Chief Executive Medical Director of the Cyprus Institute of Neurology and Genetics (CING) and the Provost of the Cyprus School of Molecular Medicine, the postgraduate school of the CING.

gene therapy, aptamers, oligonucleotides, muscle, muscular dystrophy, systematic evolution of ligands by exponential enrichment.

Talk
Use of Aptamers to Deliver Therapeutic Genetic Sequences in Muscle
Bio
Leonidas Phylactou was born in Paphos, Cyprus on 2nd January 1970. He studied Medical Biochemistry at the University of Birmingham in the UK and then did a PhD in Molecular Genetics and Gene Therapy in the same University, although most of the time was spent at the University of Connecticut Health Centre in the USA. He then moved back to the UK, to the University of Oxford as a post-doctoral scientist, where he set up a team working on gene therapy for Myotonic Dystrophy. In 1998 he established a research group at the Cyprus Institute of Neurology and Genetics working on the gene function and gene therapy. In 2005 he was appointed Head of the Department of Molecular Genetics, Function and Therapy in which, apart from the research activities, he is responsible for diagnostic services in Medical Genetics. His research interests focus on the gene therapy for muscular dystrophy, the identification of biomarkers in Myotonic Dystrophy and the investigation of molecular causes for inherited diseases. Since November 2015 he is the Chief Executive Medical Director of the Cyprus Institute of Neurology and Genetics (CING) and the Provost of the Cyprus School of Molecular Medicine, the postgraduate school of the CING.
Research Keywords
gene therapy, aptamers, oligonucleotides, muscle, muscular dystrophy, systematic evolution of ligands by exponential enrichment.

Dr. Simone Lucarini

Assistant Professor at the Department of Biomolecular Sciences, Section of Chemistry, School of Pharmacy, University of Urbino, Italy

DETAILS

Simone Lucarini studied Chemistry at the University of Bologna (Italy), where he graduated in 2000. He received his PhD in Chemistry and Pharmaceutical Sciences at the University of Urbino (Italy) in 2005. In 2003, he spent a year at the University of Kansas (USA) working with Prof. Kristin Bowman-James in the field of “anion recognition”. In 2005 he moved to the University of Tokyo (Japan) as a winner of the JSPS long term fellowship to run a post-doc with Prof. Shu Kobayashi. During this period, he developed a new synthetic method, based on an enantioselective desymmetrization of meso-aziridines, which is plausibly applicable to the production of (-) - shikimic acid, a key intermediate for the synthesis of Tamiflu. In 2007 he came back to Urbino as a post-doc and in 2013 became assistant professor in Medicinal Chemistry. His research interests range from Medicinal, Supramolecular and Organic Chemistry in order to obtain new original methods for obtaining achiral and chiral molecules of pharmaceutical-biological interest, together with the development of new synthetic methods of potential industrial interest. In detail, he is developing new methodologies for the synthesis of natural products, containing the indole nucleus, with potential antitumor and antibacterial activities. Recently, he is playing with the chemistry of sugars designing and synthesizing new glycolipids as biocompatible antibacterial agents and as emulsifying agents for pharmaceutical applications. From 2008 is professor of drug analysis at the school of pharmacy at Urbino and from 2012 is a member of the organizing committee of the European School of Medicinal Chemistry.

medicinal chemistry; NMR; synthetic organic chemistry; anticancer drugs; melatonin; bisindoles; sugar-based surfactants; adenosine A2A receptor ligands; asymmentric synthesis; macrocycles; foldamers

Bio
Simone Lucarini studied Chemistry at the University of Bologna (Italy), where he graduated in 2000. He received his PhD in Chemistry and Pharmaceutical Sciences at the University of Urbino (Italy) in 2005. In 2003, he spent a year at the University of Kansas (USA) working with Prof. Kristin Bowman-James in the field of “anion recognition”. In 2005 he moved to the University of Tokyo (Japan) as a winner of the JSPS long term fellowship to run a post-doc with Prof. Shu Kobayashi. During this period, he developed a new synthetic method, based on an enantioselective desymmetrization of meso-aziridines, which is plausibly applicable to the production of (-) - shikimic acid, a key intermediate for the synthesis of Tamiflu. In 2007 he came back to Urbino as a post-doc and in 2013 became assistant professor in Medicinal Chemistry. His research interests range from Medicinal, Supramolecular and Organic Chemistry in order to obtain new original methods for obtaining achiral and chiral molecules of pharmaceutical-biological interest, together with the development of new synthetic methods of potential industrial interest. In detail, he is developing new methodologies for the synthesis of natural products, containing the indole nucleus, with potential antitumor and antibacterial activities. Recently, he is playing with the chemistry of sugars designing and synthesizing new glycolipids as biocompatible antibacterial agents and as emulsifying agents for pharmaceutical applications. From 2008 is professor of drug analysis at the school of pharmacy at Urbino and from 2012 is a member of the organizing committee of the European School of Medicinal Chemistry.
Research Keywords
medicinal chemistry; NMR; synthetic organic chemistry; anticancer drugs; melatonin; bisindoles; sugar-based surfactants; adenosine A2A receptor ligands; asymmentric synthesis; macrocycles; foldamers

Dr. Claudio Ferrante

Università degli Studi G. d'Annunzio Chieti e Pescara | UNICH · Department of Pharmacy

DETAILS

Pharma-toxicological and phytochemical investigations on Tanacetum parthenium and Salix alba extracts: Focus on potential application as anti-migraine agents

The pharmacological research activity of Prof. C. Ferrante is focused on the following main research fields: Role of endogenous peptides on food intake and energy expenditure control; Protective effects of medicinal plants and extracts, with particular regards to inflammatory and neurodegenerative diseases; Pharmacology of central monoaminergic system; Optimization of preclinical pharmacological models for the study of the mechanism of action of drugs. Prof. C. Ferrante is co-author of 67 publications in international journals surveyed by ISI Science Citation Index.

Salix alba; Tanacetum parthenium; cortical spreading depression; apoptosis; serotonin; proteomic analysis; phytochemical analysis.

Talk
Pharma-toxicological and phytochemical investigations on Tanacetum parthenium and Salix alba extracts: Focus on potential application as anti-migraine agents
Bio
The pharmacological research activity of Prof. C. Ferrante is focused on the following main research fields: Role of endogenous peptides on food intake and energy expenditure control; Protective effects of medicinal plants and extracts, with particular regards to inflammatory and neurodegenerative diseases; Pharmacology of central monoaminergic system; Optimization of preclinical pharmacological models for the study of the mechanism of action of drugs. Prof. C. Ferrante is co-author of 67 publications in international journals surveyed by ISI Science Citation Index.
Research Keywords
Salix alba; Tanacetum parthenium; cortical spreading depression; apoptosis; serotonin; proteomic analysis; phytochemical analysis.

Dr. Giustino Orlando

University of G. d'Annunzio Chieti and Pescara, Chieti, Italy

DETAILS

Pharma-toxicological and phytochemical investigations on Harpagophytum procumbens DC. ex Meisn. water extract: potential application in colon inflammation

Harpagophytum procumbens; IBDs; Oxidative stress; Inflammation; Proteomic analysis; Phytochemicqal analysis.

Talk
Pharma-toxicological and phytochemical investigations on Harpagophytum procumbens DC. ex Meisn. water extract: potential application in colon inflammation
Research Keywords
Harpagophytum procumbens; IBDs; Oxidative stress; Inflammation; Proteomic analysis; Phytochemicqal analysis.

Dr. Mariia Nesterkina

Odessa National Polytechnic University, Odessa, Ukraine

DETAILS

Novel menthone derivatives with anticonvulsant effect

Mariia Nesterkina studied Chemistry at I.I. Mechnikov Odessa National University (Ukraine), where she graduated in 2014. Then she successfully defended her PhD thesis in Bioorganic Chemistry at the Institute of Bioorganic Chemistry and Petrochemistry (Kyiv, Ukraine) in 2017. Her research interests range from Bioorganic Chemistry – synthesis of natural occurring compounds with their further physico-chemical analysis – to Pharmacology – instigation of anticonvulsant, analgesic, anti-inflammatory activity of novel compounds. Additionally, she studies the influence of synthesized derivatives on phospholipids of artificial membranes and lipids isolated from the rat stratum corneum. Since 2019 she is Associate Professor at Odessa National Polytechnic University (Ukraine).

bioorganic chemistry; natural occurring compounds; terpenoids; synthetic organic chemistry; anticonvulsant activity; analgesic action; artificial membranes; stratum corneum lipids; TRP ion channels

Talk
Novel menthone derivatives with anticonvulsant effect
Bio
Mariia Nesterkina studied Chemistry at I.I. Mechnikov Odessa National University (Ukraine), where she graduated in 2014. Then she successfully defended her PhD thesis in Bioorganic Chemistry at the Institute of Bioorganic Chemistry and Petrochemistry (Kyiv, Ukraine) in 2017. Her research interests range from Bioorganic Chemistry – synthesis of natural occurring compounds with their further physico-chemical analysis – to Pharmacology – instigation of anticonvulsant, analgesic, anti-inflammatory activity of novel compounds. Additionally, she studies the influence of synthesized derivatives on phospholipids of artificial membranes and lipids isolated from the rat stratum corneum. Since 2019 she is Associate Professor at Odessa National Polytechnic University (Ukraine).
Research Keywords
bioorganic chemistry; natural occurring compounds; terpenoids; synthetic organic chemistry; anticonvulsant activity; analgesic action; artificial membranes; stratum corneum lipids; TRP ion channels

Prof. Dr. Maria Emília De Sousa

Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências, Químicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira 228, 4050-313, Porto, Portugal, Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Universidade do Porto, Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Mato

DETAILS

Dr. Maria M. M. Santos

Faculty of Pharmacy, Universidade de Lisboa, Avenida Professor Gama Pinto, 1649-003 Lisboa, Portugal

DETAILS

Tryptophanol-derived oxazoloisoindolinones: Novel small molecule p53 activators with promising antitumor activity

Maria M. M. Santos is Principal Researcher of the group of Medicinal Chemistry of the Faculty of Pharmacy of the University of Lisbon, she is member of the EXECUTIVE COMMITTEE of the medicinal chemistry division of Portuguese Society of Chemistry (SPQ), and she is the PORTUGUESE NAO LIAISON OFFICER of the European Federation of Medicinal Chemistry (EFMC). The ultimate goal of her research group is the development of general synthetic methods and strategies, and their application to the synthesis of bioactive molecules (e.g. NMDA receptor antagonists and p53 activators).

Cancer; MDMs; p53; tryptophanol; isoindolinone

Talk
Tryptophanol-derived oxazoloisoindolinones: Novel small molecule p53 activators with promising antitumor activity
Bio
Maria M. M. Santos is Principal Researcher of the group of Medicinal Chemistry of the Faculty of Pharmacy of the University of Lisbon, she is member of the EXECUTIVE COMMITTEE of the medicinal chemistry division of Portuguese Society of Chemistry (SPQ), and she is the PORTUGUESE NAO LIAISON OFFICER of the European Federation of Medicinal Chemistry (EFMC). The ultimate goal of her research group is the development of general synthetic methods and strategies, and their application to the synthesis of bioactive molecules (e.g. NMDA receptor antagonists and p53 activators).
Research Keywords
Cancer; MDMs; p53; tryptophanol; isoindolinone

Dr. Maurício Homem-de-Mello

Universidade de Brasília, Brasilia, Brazil

DETAILS

Mauricio Homem-de-Mello is a full time professor at Universidade de Brasília, in Brazil. His Ph.D. degree in Toxicology was obtained in 2009, at Universidade de São Paulo. He is an experimental toxicologist that has moved to the “in silico” research. Since his early studies the interest in action mechanisms of drugs was the main focus. The computational approach is now the tool that he is going deeper.

Mechanistic Toxicology, Therapeutic drugs toxicology, PK/PD, “in silico” toxicology/pharmacology, Tuberculosis therapeutics

Bio
Mauricio Homem-de-Mello is a full time professor at Universidade de Brasília, in Brazil. His Ph.D. degree in Toxicology was obtained in 2009, at Universidade de São Paulo. He is an experimental toxicologist that has moved to the “in silico” research. Since his early studies the interest in action mechanisms of drugs was the main focus. The computational approach is now the tool that he is going deeper.
Research Keywords
Mechanistic Toxicology, Therapeutic drugs toxicology, PK/PD, “in silico” toxicology/pharmacology, Tuberculosis therapeutics

Dr. Alfredo Berzal-Herranz

Department of Molecular Biology, Instituto de Parasitología y Biomedicina López-Neyra, (IPBLN-CSIC), PTS Granada, Av del Conocimiento 17, 18016 Granada, Spain

DETAILS

The 3’UTR of the West Nile Virus genomic RNA is a potential antiviral target site

Genomic RNA; ncRNAs; WNV; antiviral; RNA as target

Talk
The 3’UTR of the West Nile Virus genomic RNA is a potential antiviral target site
Research Keywords
Genomic RNA; ncRNAs; WNV; antiviral; RNA as target

Dr. Ievgeniia Iermak

University of São Paulo

DETAILS

Chemical imaging in pharmaceutics for formulation analysis, quality control, and monitoring of formulation interactions with biological tissue

Dr. Ievgeniia Iermak is the research associate in the Laboratory of Biophotonics, University of Sao Paulo, Brazil. Her research and teaching activities are dedicated to studying molecular mechanisms of cancer treatment, microbial control, and efficacy of pharmaceutical formulations. Ievgeniia has a life-long interest in advanced imaging techniques application in life sciences and pharmaceutics.

Microscopy; Raman microspectroscopy; quality control; method development; drug delivery; topical formulation

Talk
Chemical imaging in pharmaceutics for formulation analysis, quality control, and monitoring of formulation interactions with biological tissue
Bio
Dr. Ievgeniia Iermak is the research associate in the Laboratory of Biophotonics, University of Sao Paulo, Brazil. Her research and teaching activities are dedicated to studying molecular mechanisms of cancer treatment, microbial control, and efficacy of pharmaceutical formulations. Ievgeniia has a life-long interest in advanced imaging techniques application in life sciences and pharmaceutics.
Research Keywords
Microscopy; Raman microspectroscopy; quality control; method development; drug delivery; topical formulation

Mr. Christos Tsagkaris

University of Crete

DETAILS

3D Printing for medicinal chemistry in space: Crafting our way to Mars

Christos Tsagkaris is studying Medicine in the University of Crete (Heraklion, Greece). He is affiliated to the Association of European Cancel Leagues (ECL) as a Youth Ambassador for Greece and he currently serves as Editor in Chief in NovelMeds, a health science magazine focusing on Sustainable Health and in the European Student Think Tank. He has participated in several scientific conferences and events as an organizer, ambassador or presenter. He is also involved in several EU focused students associations including the Bringing Europeans Together Association - Greece and the Students Association for International Affairs. He has a keen interest on Space Medicine and Medical Humanities. Andrea Camera is studying Medicine in the University of Brescia (Brescia, Italy). Ana Sofia Mota is studying Medicine in the University of Lisbon Faculty of Medicine (Lisbon, Portugal) and Maria Lydakaki is studying Law in the University of Athens, Faculty of Law. They have all conducted research in their fields and share a keen interest in Space Science and in mutual aspects of Technology, Medicine and Law.

Space, 3D Printing, Jurisdiction

Talk
3D Printing for medicinal chemistry in space: Crafting our way to Mars
Bio
Christos Tsagkaris is studying Medicine in the University of Crete (Heraklion, Greece). He is affiliated to the Association of European Cancel Leagues (ECL) as a Youth Ambassador for Greece and he currently serves as Editor in Chief in NovelMeds, a health science magazine focusing on Sustainable Health and in the European Student Think Tank. He has participated in several scientific conferences and events as an organizer, ambassador or presenter. He is also involved in several EU focused students associations including the Bringing Europeans Together Association - Greece and the Students Association for International Affairs. He has a keen interest on Space Medicine and Medical Humanities. Andrea Camera is studying Medicine in the University of Brescia (Brescia, Italy). Ana Sofia Mota is studying Medicine in the University of Lisbon Faculty of Medicine (Lisbon, Portugal) and Maria Lydakaki is studying Law in the University of Athens, Faculty of Law. They have all conducted research in their fields and share a keen interest in Space Science and in mutual aspects of Technology, Medicine and Law.
Research Keywords
Space, 3D Printing, Jurisdiction

Dr. Šárka Pospíšilová

Regional Centre of Advanced Technologies and Materials (RCPTM), Palacký University

DETAILS

Šárka Pospíšilová is a Ph.D student at Regional Centre of Advanced Technologies and Materials (RCPTM), Palacký University in Olomouc, Czech Republic. She obtained her Doctor of Pharmacy degree (PharmDr.) at University of Veterinary and Pharmaceutical Sciences in Brno, Czech Republic. Dr. Pospíšilová deepened her professional knowledge at several research-fellowships abroad, such as the Faculty of Pharmacy of the University of Ljubljana (Slovenia), the Department of Biological Sciences of the Cork Institute of Technology (Ireland), the Center for Agricultural Research of the Hungarian Academy of Sciences (Hungary), etc. Her research focuses on the investigation of antimicrobial activity of newly synthesized compounds, including (aza)naphthalenes, thiosemicarbazones, salicylamides, derivatives of carbamic acid and metal complexes. These types of compounds as antimicrobially multi-target agents tested against wide spectrum of microorganisms, such as staphylococci, enterococci, mycobacteria, and various plant pathogens, seem to be promising for overcoming resistance/multi-drug resistance of microorganisms. Her current research activities are mainly devoted to anti-biofilm active compounds and interaction with quorum-sensing. She is an author/co-author of 2 patent applications, 11 peer-reviewed scientific publications, and many contributions at international conferences and workshops.

antibacterial activity, antimycobacterial activity, biofilm, structure-activity relationships

Bio
Šárka Pospíšilová is a Ph.D student at Regional Centre of Advanced Technologies and Materials (RCPTM), Palacký University in Olomouc, Czech Republic. She obtained her Doctor of Pharmacy degree (PharmDr.) at University of Veterinary and Pharmaceutical Sciences in Brno, Czech Republic. Dr. Pospíšilová deepened her professional knowledge at several research-fellowships abroad, such as the Faculty of Pharmacy of the University of Ljubljana (Slovenia), the Department of Biological Sciences of the Cork Institute of Technology (Ireland), the Center for Agricultural Research of the Hungarian Academy of Sciences (Hungary), etc. Her research focuses on the investigation of antimicrobial activity of newly synthesized compounds, including (aza)naphthalenes, thiosemicarbazones, salicylamides, derivatives of carbamic acid and metal complexes. These types of compounds as antimicrobially multi-target agents tested against wide spectrum of microorganisms, such as staphylococci, enterococci, mycobacteria, and various plant pathogens, seem to be promising for overcoming resistance/multi-drug resistance of microorganisms. Her current research activities are mainly devoted to anti-biofilm active compounds and interaction with quorum-sensing. She is an author/co-author of 2 patent applications, 11 peer-reviewed scientific publications, and many contributions at international conferences and workshops.
Research Keywords
antibacterial activity, antimycobacterial activity, biofilm, structure-activity relationships

Ms. Cristina Almeida

University of Porto

DETAILS

My scientific experience started during my BSc graduation at Biochemistry (Faculty of Sciences of the University of Porto and in the Abel Salazar’s Biomedical Institute of the University of Porto), when in the final year (2017), I developed a research project, under the curricular unit “Projeto”. During this period I worked on a project related to the study of cannabinoid compounds as anti-cancer drugs in estrogen receptor-positive breast cancer cells, in the Faculty of Pharmacy of the University of Porto, under the supervision of Doctor Cristina Amaral and Prof. Doctor Natércia Teixeira. This work allowed two poster presentations, one at the 12th YES – Young European Scientist Meeting and at the other on I International Congress about Cannabis and its Derivatives: Health, Education and Law. The abstract submitted to the 12th YES – Young European Scientist Meeting was further published at the Porto Biomedical Journal (see below). As my ambition was to improve my professional skills and my scientific knowledge, in the end of 2017 I started the Master degree in Biochemistry in the Faculty of Sciences of the University of Porto and in the Abel Salazar’s Biomedical Institute of the University of Porto. Currently, I am finishing my MSc thesis project, which was performed in the Faculty of Sciences of the University of Porto and in the Faculty of Pharmacy of the University of Porto, under the supervision of Doctor Cristina Amaral, Prof. Doctor Natércia Teixeira and Prof. Doctor Pedro Alexandrino Fernandes. The work presented at this conference is part of the project that I have been developing during my MSc thesis. The project aims to discover multi-target compounds for estrogen receptor-positive breast cancer treatment, as this represents a novel and promising therapeutic approach for this type of cancer.During the last year, and under this project, I presented two posters at the Encontro de Jovens Investigadores de Biologia Computacional e Estrutural (EJIBCE) and at the 14th YES – Young European Scientist Meeting, as well as, an oral presentation at the 12º Encont

Talk
My scientific experience started during my BSc graduation at Biochemistry (Faculty of Sciences of the University of Porto and in the Abel Salazar’s Biomedical Institute of the University of Porto), when in the final year (2017), I developed a research project, under the curricular unit “Projeto”. During this period I worked on a project related to the study of cannabinoid compounds as anti-cancer drugs in estrogen receptor-positive breast cancer cells, in the Faculty of Pharmacy of the University of Porto, under the supervision of Doctor Cristina Amaral and Prof. Doctor Natércia Teixeira. This work allowed two poster presentations, one at the 12th YES – Young European Scientist Meeting and at the other on I International Congress about Cannabis and its Derivatives: Health, Education and Law. The abstract submitted to the 12th YES – Young European Scientist Meeting was further published at the Porto Biomedical Journal (see below). As my ambition was to improve my professional skills and my scientific knowledge, in the end of 2017 I started the Master degree in Biochemistry in the Faculty of Sciences of the University of Porto and in the Abel Salazar’s Biomedical Institute of the University of Porto. Currently, I am finishing my MSc thesis project, which was performed in the Faculty of Sciences of the University of Porto and in the Faculty of Pharmacy of the University of Porto, under the supervision of Doctor Cristina Amaral, Prof. Doctor Natércia Teixeira and Prof. Doctor Pedro Alexandrino Fernandes. The work presented at this conference is part of the project that I have been developing during my MSc thesis. The project aims to discover multi-target compounds for estrogen receptor-positive breast cancer treatment, as this represents a novel and promising therapeutic approach for this type of cancer.During the last year, and under this project, I presented two posters at the Encontro de Jovens Investigadores de Biologia Computacional e Estrutural (EJIBCE) and at the 14th YES – Young European Scientist Meeting, as well as, an oral presentation at the 12º Encont

Dr. Patrícia Rijo

Universidade Lusófona de Humanidades e Tecnologias, Lisbon, Portugal

DETAILS

Patrícia Dias de Mendonça Rijo has a graduation in Chemistry by the Faculty of Sciences at the University of Lisbon (FCUL), and Master and PhD degrees in Pharmaceutical and Therapeutic Chemistry by the Faculty of Pharmacy at the University of Lisbon (FFUL). Currently, she is Assistant Professor at the School of Sciences and Health Technologies (ECTS) at the Universidade Lusófona de Humanidades e Tecnologias (ULHT, Lisbon, Portugal) since 2001, where she is responsible for the Coordination of several disciplines in related domains of Chemistry, namely, Medicinal Chemistry and Pharmacognosy. Moreover, she is a member of the Scientific Council of ECTS (ULHT). She has focused her research in the medicinal chemistry, phytochemistry and pharmacognosy areas with particular emphasis in Natural Products Chemistry. She published more than seventy papers in international peer-reviewed journals and has over two hundred communications (oral and panel) presented at both national and international meetings and conferences. In addition, she has two international registered patents.

Bio
Patrícia Dias de Mendonça Rijo has a graduation in Chemistry by the Faculty of Sciences at the University of Lisbon (FCUL), and Master and PhD degrees in Pharmaceutical and Therapeutic Chemistry by the Faculty of Pharmacy at the University of Lisbon (FFUL). Currently, she is Assistant Professor at the School of Sciences and Health Technologies (ECTS) at the Universidade Lusófona de Humanidades e Tecnologias (ULHT, Lisbon, Portugal) since 2001, where she is responsible for the Coordination of several disciplines in related domains of Chemistry, namely, Medicinal Chemistry and Pharmacognosy. Moreover, she is a member of the Scientific Council of ECTS (ULHT). She has focused her research in the medicinal chemistry, phytochemistry and pharmacognosy areas with particular emphasis in Natural Products Chemistry. She published more than seventy papers in international peer-reviewed journals and has over two hundred communications (oral and panel) presented at both national and international meetings and conferences. In addition, she has two international registered patents.

Ms. Eduarda Fernandes

University of Minho

DETAILS

Drug (re-)design guided by biophysical characterization of interactions with biomimetic membranes

Eduarda Fernandes graduated in Biomedical Sciences by University of Beira Interior in 2014 and is a MSc in Biophysics and Bionanosystems from University of Minho (2017). From 2017 to 2018 she was promotor and founder of the project “EyeOnDrug”, that was based on developing nanotechnological solutions for drug and formulation profiling, for which she was awarded with an entrepreneur fellowship funded by IAPMEI, Portugal. In 2018 she continued developing this work as a research fellow in Centre of Physics of the Universities of Minho and Porto (CF-UM-UP), where she is currently a first year PhD student in Materials Engineering. The scientific research activity of Eduarda has been focused on the application of several biophysical and physical‐chemical techniques to characterize the interaction between bioactives, including newly-synthesized drugs, and biomimetic interfaces to establish a pharmacokinetic profiling to support drug design/development and formulation development. Among other activities, Eduarda has participated in several international and national conferences presenting 7 oral communications as first author (2 of which as invited speaker) and 5 posters, two of which was awarded as the Best Poster. Moreover, she has published 3 papers (first author of 2 papers) in journals of high impact and quartile 1 in the area of pharmaceutics, molecular sciences and analytical chemistry. She is also co-author of two book chapters (accepted for publication in “Functional lipid nanosystems in cancer” and “Nanoparticles for Brain Drug Delivery”).

pharmacokinetics; ADME; biophysics; biomimetic membrane models

Talk
Drug (re-)design guided by biophysical characterization of interactions with biomimetic membranes
Bio
Eduarda Fernandes graduated in Biomedical Sciences by University of Beira Interior in 2014 and is a MSc in Biophysics and Bionanosystems from University of Minho (2017). From 2017 to 2018 she was promotor and founder of the project “EyeOnDrug”, that was based on developing nanotechnological solutions for drug and formulation profiling, for which she was awarded with an entrepreneur fellowship funded by IAPMEI, Portugal. In 2018 she continued developing this work as a research fellow in Centre of Physics of the Universities of Minho and Porto (CF-UM-UP), where she is currently a first year PhD student in Materials Engineering. The scientific research activity of Eduarda has been focused on the application of several biophysical and physical‐chemical techniques to characterize the interaction between bioactives, including newly-synthesized drugs, and biomimetic interfaces to establish a pharmacokinetic profiling to support drug design/development and formulation development. Among other activities, Eduarda has participated in several international and national conferences presenting 7 oral communications as first author (2 of which as invited speaker) and 5 posters, two of which was awarded as the Best Poster. Moreover, she has published 3 papers (first author of 2 papers) in journals of high impact and quartile 1 in the area of pharmaceutics, molecular sciences and analytical chemistry. She is also co-author of two book chapters (accepted for publication in “Functional lipid nanosystems in cancer” and “Nanoparticles for Brain Drug Delivery”).
Research Keywords
pharmacokinetics; ADME; biophysics; biomimetic membrane models

Dr. Edeildo Ferreira da Silva-Júnior

Federal University of Alagoas

DETAILS

Design, synthesis and in vitro biological evaluation of acrylamide derivatives against Chikungunya virus

Edeildo Ferreira da Silva-Júnior studied Pharmacy at the Federal University of Alagoas, Maceió – Brazil. Subsequently, he received his Master’s degree in Pharmaceutical Sciences by the Federal University of Alagoas, Brazil, as well. Since his Master degree, he is working in the medicinal chemistry of Neglected Tropical Diseases (NTD’s), collecting valuable experiences on the researches addressed to the development of novel synthetic compounds with activity against Leishmania spp. and Trypanosoma cruzi, in association with collaborators from the University of Strasbourg – France. He has Ph.D. degree in Chemistry and Biotechnology, with focus on the Medicinal and Biological Chemistry, obtained at the Federal University of Alagoas. During his Ph.D., he developed part of his project and thesis at the Institute of Pharmacy and Biochemistry from the Johannes Gutenberg University of Mainz, Germany. Current, he holds a post-doctoral position at the Federal University of Alagoas, where he acts as Project-Leader and Laboratory-Head at the Institute of Pharmaceutical Sciences. Furthermore, he develops projects involving collaborators from the Johannes Gutenberg University of Mainz and Würtzburg University (Germany). He has several patents and high-qualified publications in organic and medicinal chemistry fields, such as Bioorganic Chemistry, Molecules, Current Topics in Medicinal Chemistry, Biosensors & Bioelectronics, Bioorganic & Medicinal Chemistry, Current Drug Metabolism, Biomedicine & Pharmacotherapy, and others.

Virtual screening; acrylamides; Chikungunya; molecular docking; E protein

Talk
Design, synthesis and in vitro biological evaluation of acrylamide derivatives against Chikungunya virus
Bio
Edeildo Ferreira da Silva-Júnior studied Pharmacy at the Federal University of Alagoas, Maceió – Brazil. Subsequently, he received his Master’s degree in Pharmaceutical Sciences by the Federal University of Alagoas, Brazil, as well. Since his Master degree, he is working in the medicinal chemistry of Neglected Tropical Diseases (NTD’s), collecting valuable experiences on the researches addressed to the development of novel synthetic compounds with activity against Leishmania spp. and Trypanosoma cruzi, in association with collaborators from the University of Strasbourg – France. He has Ph.D. degree in Chemistry and Biotechnology, with focus on the Medicinal and Biological Chemistry, obtained at the Federal University of Alagoas. During his Ph.D., he developed part of his project and thesis at the Institute of Pharmacy and Biochemistry from the Johannes Gutenberg University of Mainz, Germany. Current, he holds a post-doctoral position at the Federal University of Alagoas, where he acts as Project-Leader and Laboratory-Head at the Institute of Pharmaceutical Sciences. Furthermore, he develops projects involving collaborators from the Johannes Gutenberg University of Mainz and Würtzburg University (Germany). He has several patents and high-qualified publications in organic and medicinal chemistry fields, such as Bioorganic Chemistry, Molecules, Current Topics in Medicinal Chemistry, Biosensors & Bioelectronics, Bioorganic & Medicinal Chemistry, Current Drug Metabolism, Biomedicine & Pharmacotherapy, and others.
Research Keywords
Virtual screening; acrylamides; Chikungunya; molecular docking; E protein

Keynote Presentations

List of accepted submissions (113)

Id Title Authors Video Poster
sciforum-028149 3D Printing for medicinal chemistry in space: Crafting our way to Mars

Christos Tsagkaris, Andrea Camera, Ana Sofia Mota, Maria Lydakaki

Submitted: 26 Oct 2019

Abstract: Show Abstract
Christos Tsagkaris, Andrea Camera, Ana Sofia Mota, Maria Lydakaki Video Thumbnail Poster PDF Show Abstract

Comment
sciforum-028148 3D Printing in Medicinal Chemistry: Applications, Prospective and Consideration

Evangelia Petropoulou, Nikolaos Sevdalis, Christos Tsagkaris, Aggeliki Vakka

Submitted: 26 Oct 2019

Abstract: Show Abstract
Evangelia Petropoulou, Nikolaos Sevdalis, Christos Tsagkaris, Aggeliki Vakka N/A Poster PDF Show Abstract

Comment
sciforum-028091 A novel approach for ER+ breast cancer treatment: A new compound that modulates aromatase and ER

Cristina Almeida, Ana Oliveira, Pedro Fernandes, Georgina Correia-da-Silva, Maria João Ramos, Tiago Augusto, Natércia Teixeira, Cristina Amaral

Submitted: 25 Oct 2019

Abstract: Show Abstract
Cristina Almeida, Ana Oliveira, Pedro Fernandes, Georgina Correia-da-Silva, Maria João Ramos, Tiago Augusto, Natércia Teixeira, Cristina Amaral Video Thumbnail Poster PDF Show Abstract

Comment
sciforum-028663 A pyrazole-containing copper coordination framework : an investigation into its Hirshfeld surface analysis, magnetic behavior and biological activity

Amani Direm, Olufunso Abosede, Mohammed S. M. Abdelbaky, Cemal Parlak, Santiago García-Granda, Nourredine Benali-Cherif

Submitted: 13 Nov 2019

Abstract: Show Abstract
Amani Direm, Olufunso Abosede, Mohammed S. M. Abdelbaky, Cemal Parlak, Santiago García-Granda, Nourredine Benali-Cherif N/A Poster PDF Show Abstract

Comment
sciforum-028480 Abietane Diterpenoids from Plectranthus spp. as a potential new class of Protein Kinase C Modulators

Patrícia Rijo

Submitted: 03 Nov 2019

Abstract: Show Abstract
Patrícia Rijo Video Thumbnail Poster PDF Show Abstract

Comment

List of Authors (453)




Mohammed S. M. Abdelbaky

Olufunso Abosede



Adegbenro Adegunloye




António Aguiar



Andreia Almeida


Mariana Almeida


Joana Almeida




Basam Alzoubi

Cristina Amaral


Roberto Amílcar

Nurul Suhaili Amirah Mamat

Claire Andréjak



Julius Arannilewa

Margarida Duarte Araújo


João Araújo-Júnior

Darko Ašanin



Instructions for Authors

Instructions for Authors

Submissions should be done by the authors online by registering with www.sciforum.net, and using the "Start New Submission" function once logged into system.

Researchers interested in attending the conference must submit, on this website and not later than 25 October 2019, an abstract of the work they intend to present.

After the abstract is accepted by the Scientific Committee (1-5 days after receipt of the abstract), the authors will be invited to prepare a full description of their work preferably under the form of a PowerPoint presentation, and to upload it before 30 October 2019 to ensure final check.

The presentations will be accessible on https://sciforum.net/conference/ECMC2019 during the time of the conference.

Authors are encouraged to prepare a presentation using the template provided by the Conference. Slides will be displayed directly in the website using Sciforum.net's proprietary slides viewer. They can be prepared in exactly the same way as for any traditional conference where research results can be presented. Slides should be converted to the PDF format before submission so that our process can easily and automatically convert them for online displaying.

The following organization is recommended for your presentation:

  • Length of the presentation: no more than 30 slides
  • Slide 1 (strictly one slide): Title, Authors’ names, Affiliation(s), email address of the corresponding Author, and, not mandatory, logos of the laboratory and/or institution;
  • Slide 2 (strictly one slide): Graphical Abstract, repeat the title of the presentation but avoid other text as far as possible;
  • Slide 3 (strictly one slide): Abstract (max 200 words) and 3-5 keywords separated by semicolons;
  • Slide 4 and following slides: should contain (in the given sequence) Introduction, Results and Discussion; Conclusions.
  • Last slide: Acknowledgments and, not mandatory, logos of sponsors of the work.

Authors can also submit their work under the form of a poster by using the template provided by the Conference. Notice that posters will not be evaluated for the travel award.

Conference Awards

Best Presentation Award

The Awards
Best Presentation Award
This year, as a sponsor, Pharmaceuticals would like to award the best presentation as elected by the members of the scientific committee. The Award will consist of 500 Swiss Francs. We look forward to posting your contributions.
Keynote Speaker Award
This year, as a sponsor, Pharmaceuticals would like to award the best Keynote Speaker as elected by the members of the scientific committee. The Award will consist of 300 Swiss Francs. We look forward to your contributions.
Best Poster Award
This year, as a sponsor, Pharmaceuticals would like to award the best poster as elected by the members of the scientific committee. The Award will consist of 200 Swiss Francs. We look forward to your contributions.
Terms and Conditions:

Criteria

1. Full PPT presentation must be submitted to ECMC-5.
2. The quality of the presentation.
3. The scientific content of the presentation

Evaluation

1. Each Evaluation Committee member will give an assessment for each applicant in terms of the criteria outlined above.
2. Total score for each presentation will be ranked, from highest to lowest.
3. If two or more students get the same score, further evaluation will be carried out.
4. All decisions made by the Evaluation Committee are final.

Sponsors and Partners

Organizers


Media partners

Exhibition Hall

Copyright

MDPI, the publisher of the Sciforum.net platform, is an open access publisher. We believe that authors should retain the copyright to their research works. Hence, by submitting a contribution to this conference, the authors retain the copyright of their contribution, but they grant MDPI AG the non-exclusive right to publish this contribution online on the Sciforum.net platform. This means the authors can easily submit their contribution to any scientific journal at a later stage and transfer the copyright to its publisher (if required by that publisher).

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