When considering a disorder without tumor redox metabolism, a highlight is glioblastoma multiforme. These are malignant tumors originating in astrocytes and oligodendroglia, highly aggressive and of rapid development, and for that reason the death can occur in a few months after the diagnosis. The study aims to expose an overview of the potential of physical activity against the redox system in glioblastoma multiforme. A narrative review used as a method to expose a pertinent appreciation of the topic. To initiate an investigation, a guiding question was elaborated for the conduct of the research process, which occurred in electronic databases, such as Pubmed Central, Scielo and Scopus. Answers to the question "what is the influence of physical exercise on the redox metabolism of glioblastoma multiforme?" Were chosen to compose the final sample of studies. The results reveal that knowledge of oxidative stress processes against glioblastomas can provide insights into the different managements that slow the progress of the disease and decrease its morbidity and mortality. A positive regulation of mRNA from antioxidant enzymes was corrected, suggestion of autophagy, damaging an anti-invasive effect of the tumor. However, other authors did not observe a reduction in the tumor. Although divergent, the information is promising for the clinical management and quality of life of patients.

People use medicinal plants as diet, and for treatment of infectious and noninfectious diseases and they use brief procedures like frying and cooking to do so. Medicinal plants; Moringa oleifera, Azadirachta indica, and Lepidium sativum which is believed to have active components that help to treat and manage various diseases were investigated for their antibacterial activities against Staphylococcus aureus, Salmonella Typhi, Streptococcus agalactiae and Shigella boydii. Solvent methanol and aqueous were used for extraction of crudes by means of maceration. Susceptibility testing was determined by using disc diffusion method and Minimum inhibitory concentration was determined by broth dilution method. Heat treated plant material activity against test pathogen was aimed to identify resistance capacity of plant material at different interval of time and temperature. All plant extracts under study was active against all tested pathogen after exposure to 45 °C for 30 min. The antibacterial activities of the non-heat-treated extracts of Azadirachta indica were relatively low; the results of this study show that extracts of Azadirachta indica have better residual antibacterial activities. Methanol extracts of all plant leaves showed highest activity as compared to the aqueous extracts. This is probably assigning the choice of extraction solvent for extracting desired active phytochemical from plants. Many of the people in the study area were illiterate and they did not have awareness about the ways use of medicinal plants. They use the medicinal plants by cooking and frying for different purposes. In the main, plant material can be affected as the temperature of treatment is increases with respect to various times of exposures.

PURPOSE

COVID-19 heightened awareness of primary caregivers (parents, aunts, uncles, grandparents, etc.) as fundamentally important in mentoring adolescents and youth toward avoidance of current cultural pitfalls. Proximity, but also passionate and consistent involvement, interest, and emotional investment, affords them a unique opportunity. S&RHK is an efficient, effective, and measurable health outcome worthy of consideration as “low-hanging fruit”, with the potential to reap significant long-term benefits in the spectrum of Social Determinants of Health (SDOH).

METHODS

A 50-item survey was administered to men and women, aged 20-89 years, in two US outpatient, primary care clinics, 1 urban, 1 suburban. 18 questions gauged S&RHK, with 1 correct answer per question. Data coding and analysis used IBM-SPSS. Statistical analysis included: Pearson correlation, t, and Chi-squared tests; with significance at p <0.05.

RESULTS

Of 352 patients surveyed; 81.5% were women and 18.5% men. Mean age was 55.2 ± 14.6 years. 84.1% were African-American. 62.3% had incomes ≤ $50,000. Average years of formal education were 14.1± 2.5, and lower in older adults. 42.3% of those with formal sex education stated that it was sufficient; 16.8% insufficient. 35.2 % reported no such education. Mean S&RHK score was 10.2 ± 3.6, (max. = 18). 97% stated having sufficient S&RHK was important. S&RHK scores correlated positively with years of education, income, and use of digital communication ≥11x/week (p<0.001); negatively with age (p<0.001). Effect of face-to-face communication on S&RHK did not reach statistical significance.

CONCLUSIONS

The positive association of S&RHK with technological (but not face-to-face) communication could possibly be traced back to education and income: two SDOH. Those living alone (also having lower incomes) and older adults (irrespective of income) scored lower. Intriguing is the effect of traditional two-parent or multigenerational households, in bridging the S&RHK gap for older adults and preparing them as mentors to the next generation.

Objectives: Cardiovascular disease has been the leading cause of death in both sexes in Serbia in the last decades. The aim of this study was to examine sex differences in risk factors for myocardial infarction in Serbia.

Materials and methods: A hospital-based case-control study analyzing risk factors for myocardial infarction was conducted at the University Clinical Centre in Kragujevac (Serbia). We investigated the following risk factors: occupation, education level, marital status, family history, psychosocial distress, body mass index, blood pressure, cholesterol level, diabetes mellitus, smoking status, alcohol use, and menopause. Logistic regression analysis was used to determine odds ratio (OR) with 95% confidence intervals (95% CI).

Results: Our study comprised 374 participants: 187 newly diagnosed patients with myocardial infarction and 187 controls. Cases and controls were individually matched by gender, age (±2 years), and place of residence (rural / urban). Analysis of cardiovascular risk factors by sex revealed that the increase of risk for acute myocardial infarction was associated with obesity (OR=2.17; 95%CI=1.13-4.16), stressful life events in personal history (OR=2.88; 95%CI=1.53-5.43) and cholesterol level (OR=7.57; 95%CI=2.02-28.43) in men, while diabetes mellitus (OR=5.19; 95%CI=1.60-6.80), smoking (OR=3.08; 95%CI=1.45-6.53) and menopause (OR=5.62; 95%CI=1.10-28.76) were associated with increased risk in women.

Conclusion: Our study noted sex differences in risk factors for myocardial infarction. Additional analytic epidemiological studies addressing cardiovascular risk factors are needed.