Podophyllotoxin(1), which shows high antitumor activity, is isolated from Podophyllum pelatum L. or Podophyllum emodi L.. But, because of its serious side-effect, it cannot be used as antitumor agent clinically. Its semisynthetic derivatives, Etoposide(2) and Teniposide(3), are wide-used, important anticancer drugs[1] (Chart 1). However, they have several limitations such as poor water solubility, metabolic inactivation and development of drug resistance. To overcome these limitations, many derivatives of podophyllotoxin have been synthesized in many laboratories[2]. It has been recognized thatßsubstitution at C-4 position is necessary to the compounds with high activity. Our group has established a methodology to synthesize 4-b -substituted derivative of podophyllotoxin stereoselectively[2b]. This communication report the synthesis of 4-b -cyano-4-deoxy-4’-demethylepipodophyllotoxin, which is a important intermediate for synthesizing 4-b -carbon subtituted derivative.

Hydrodistillation of Amomum subulatum, Cinnamomum verum, Coriandrum sativum, Cuminum cyminum, Elettaria cardamomum, Myristica fragrans (Mace), and Myristica fragrans (Nutmeg) purchased from local spice markets yielded essential oils which contained 1,8-cineole (72.7%), cinnamaldehyde (79.8%), linalool (78.1%), cuminaldehyde (37.4%), 1,8-cineole (30.7%), terpinen-4-ol (20.0% and 31.3%), respectively, as main constituents determined by GC/MS. Antifungal activity of the resulting essential oils against various pathogenic fungi (Aspergillus flavus, A. niger, Candida albicans, Fusarium oxysporum var. lycopersici, Microsporum canis, Pseudallescheria boydii, Trichopyton mentagrophytes and T. simii) was investigated.

ChemSites ( http://www.ch.cam.ac.uk/ChemSitesIndex.html ) is a list of University Chemistry Departments and Chemistry-related journals around the world. This article describes what makes it distinct from other lists, and justifies the existence of more than one such list

Marvin is an applet package for drawing and visualizing chemical structures and substructures. Anyone with a webbrowser can use Marvin, no special programs or plugins are required. MarvinSketch/AWT and MarvinView/AWT are written in Java 1.0, so they even work in older web browsers. Furthermore, Marvin has special support for future browsers that will implement Java 2. MarvinSketch/Swing and MarvinView/Swing are the modern versions of the applets, Java 2 or Java 1.1 plus Swing are required for them to work. (Swing is a library of new style GUI components.)

JChem is a development tool written in Java for accessing chemical data over the Internet or in Intranets by web browsers. It stores structures in a relational database system on a server. JChem was designed to be portable on both the client and the server side. It supports most operating systems, web browsers, database management systems, and web servers.

The open source program JChemPaint for drawing 2D chemical structure, its current features, its envisioned further development and the principles enabling researchers and students at places all over the world to collaboratively develop such a program are described

Incremental calculation of 13C chemical shifts of substituted benzenes, pyridines, pyridazines, biphenyls, 2,2´- bipyridyls, naphthalines, quinolines with and without ortho correction and numerical as well as graphical output, a 1HWizard for interpretation of 1H NMR spectra, a small 13C NMR data bank and a Complete Line Shape Analysis simulation of the non-coupled AB-case. Further, a number of surveys concerning chemical shifts (1H, 13C, 11B, 15N, 17O, 31P, 19F), nJH,H coupling constants, NMR solvents (physical data and 1H/13C NMR spectra) and the Periodical Table of the NMR elements (nucleus data, NMR characteristics) can be employed for structural search

We report the experience and the recent improvement of the MolBank section at the http://www.molbank.org server and the journal Molecules (http://www.mdpi.org/molecules/, ISSN 1420-3049). The monthly chemistry journal Molecules' new column "MolBank" was launched in 1997 to publish short notes of onepaper one-page for one structure.