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Fullerenyl-1,2,3-triazoles: synthesis and cytotoxic activity
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Academic Editor: Julio A. Seijas
Published:
13 November 2021
by MDPI
in The 25th International Electronic Conference on Synthetic Organic Chemistry
session Bioorganic, Medicinal and Natural Products Chemistry
Abstract:
For the first time, the reaction of fullerenyl azide with terminal acetylenes has been used to synthesize previously undescribed 1-butyl-2-triazolylfullerenes, in which the heterocyclic fragment is directly attached to the fullerene backbone. Water-soluble complexes of the synthesized adducts of fullerene with polyvinylpyrrolidone showed high cytotoxic activity towards tumor cells of the Jurkat, K562, U937 lines.
Keywords: fullerene, triazolylfullerenes, cytotoxic activity, tumor cells of the Jurkat, K562, U937 lines.
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