Secondary metabolites found in the medicinal plants play important role in curing different diseases and used as important raw materials for the manufacturing of traditional and modern medicine. These medicinal plants like Annona reticulata with Allium sativum, Allium fistolisum and Brassica oleraceae reduces various risk factors associated with several diseases. It has been shown to inhibit enzymes involved in lipid synthesis, decrease platelet aggregation, prevent lipid peroxidation of oxidized erythrocytes and LDL, increase antioxidant status, and inhibit angiotensin converting enzyme. It also reduces cholesterol, inhibits platelet aggregation, reduces blood pressure, and increases antioxidant status. Therefore, our aim was to compare the different secondary metabolites present in the crude extracts of aqueous and methanolic. Phytochemicals screening revealed the results that alkaloids, reducing sugar, flavonoids, glycosides, cardiac glycosides, tannin and phenolic compounds, saponins, amino acid & triterpenoids It indicated that bioactive components are present in these plants that could be accounted for its pharmacological effects. Thus, the results support the uses of these plant species in traditional medicine.