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Synthesis of new highly functionalized nicotinic acids
1 , * 1, 2, 3 , 3 , 3
1  Kuban State University
2  ChemEx Lab, Vladimir Dal’ Lugansk National University
3  North Caucasus Federal University
Academic Editor: Julio A. Seijas

https://doi.org/10.3390/ecsoc-25-11800 (registering DOI)
Abstract:

2,2-Dimethyl-5-((phenylamino)methylene)-1,3-dioxane-4,6-dione, prepared by ternary condensation of Meldrum’s acid with triethyl orthoformate and aniline, reacts with cyanoacetic acid hydrazide in the presence of KOH to give 1-amino-5-cyano-2-oxo-1,2-dihydropyridine-3-carboxylic acid, which is useful as drug precursors or perspective ligands.

Keywords: enamino-1,3-dicarbonyls, cyanoacethydrazide, nicotinic acid

 
 
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