Synthesis of new highly functionalized nicotinic acids

Alena Russkih; Victor Dotsenko; Nicolai Aksenov; Inna Aksenova

Previous Article in event

Synthesis of N-(hydroxymethylene)thioamides by N- hydroxymethylation of 2-cyanothioacrylamides

Next Article in event

Synthesis of kinase inhibitors utilizing thiophile-free Eschenmoser reaction of bromoindol-2-ones and thioamides

Synthesis of new highly functionalized nicotinic acids

¹,

^{*

2, 3, 4},

⁴,

⁴

¹ Kuban State University
² Department of Organic Chemistry and Technologies, Kuban State University, 149 Stavropolskaya Str., 350040 Krasnodar, Russia
³ ChemEx Lab, Vladimir Dal’ Lugansk National University
⁴ North Caucasus Federal University

Academic Editor: Julio A. Seijas

Published: 14 November 2021 by MDPI in The 25th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-25-11800 (registering DOI)

Abstract:

2,2-Dimethyl-5-((phenylamino)methylene)-1,3-dioxane-4,6-dione, prepared by ternary condensation of Meldrum’s acid with triethyl orthoformate and aniline, reacts with cyanoacetic acid hydrazide in the presence of KOH to give 1-amino-5-cyano-2-oxo-1,2-dihydropyridine-3-carboxylic acid, which is useful as drug precursors or perspective ligands.

Keywords: enamino-1,3-dicarbonyls, cyanoacethydrazide, nicotinic acid

View paper

69 Reads
0 Recommendations