Sonogashira versus Stephens-Castro Mediated Synthesis of o-Phenylethynylbenzoic Acids, Convenient Precursors of 3-Phenylisocoumarins

Ramón Estévez; Juan Estévez; Francisco Reboredo

doi:10.3390/ecsoc-12-01201

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Sonogashira versus Stephens-Castro Mediated Synthesis of o-Phenylethynylbenzoic Acids, Convenient Precursors of 3-Phenylisocoumarins

Ramón J. Estévez

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Juan C. Estévez

^*,

Francisco J. Reboredo

¹ Departamento de Química Orgánica. Universidade de Santiago de Compostela. 15782 Santiago de Compostela, ESPAÑA

Published: 29 November 2008 by MDPI in The 12th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-12-01201

Abstract: We describe herein two synthetic approaches to 3-phenyl-5-nitro-isocoumarines, both based on a nitro-facilitated cyclization of o-phenylethynylbenzoic acids obtained by Sonogashira or Stephens-Castro mediated coupling of o-yodobenzoic acids and phenylacetilenes

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Ramón Estévez

Juan Estévez

Francisco Reboredo