Convenient synthesis of some methyl-N-[2-(6-oxo-3-p-tolyl-5,6-dihydro-4H-pyridazin-1-yl)-acetamide]alkanoates

S. El Rayes

doi:10.3390/ecsoc-12-01228

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Convenient synthesis of some methyl-N-[2-(6-oxo-3-p-tolyl-5,6-dihydro-4H-pyridazin-1-yl)-acetamide]alkanoates

S. M. El Rayes

¹ Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt

Published: 08 November 2008 by MDPI in The 12th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-12-01228

Abstract: An efficient one-pot synthesis of methyl-N-[2-(6-oxo-3-p-tolyl-5,6-dihydro-4Hpyridazin-1-yl)-acetamide]alkanoates 5a-j and dipeptides 8a-f was successfully realized starting from amino acid esters 4 and azides 3, 7, respectively. The hydrazide 6a was further reacted with selected aldehydes to give the corresponding hydrazones 9a-c.

Keywords: amino acids, dipeptide, azide coupling, dihydro-2H-pyridazin-3-one, hydrazones

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