Pyrazinecarboxamides, Their Synthesis and Evaluation as Potential Herbicides

¹ Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
² Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská Dolin CH-2, 842 15 Bratislava, Slovak Republic
³ Zentiva a. s., U kabelovny 130, 102 37 Prague 10, Czech Republic

Published: 27 November 2008 by MDPI in The 12th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural Products

https://doi.org/10.3390/ecsoc-12-01240

Abstract: The condensation of substituted pyrazinecarboxylic acid chlorides with ring substituted anilines yielded nine substituted pyrazinecarboxylic acid amides. The photo-synthesis inhibition activity of a series of pyrazine derivatives was investigated. The synthesis, analytical and biological data of the newly synthesized compounds are presented in this paper. The most active inhibitor of the oxygen evolution rate in spinach chloroplasts was 2-(5-methyl-pyrazine-2-carboxamido)benzoic acid (9, IC50 = 85.0 µmol·L-1).

Keywords: synthesis of pyrazinecarboxamides, photosynthesis inhibiting activity, lipophilicity

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Matúš Peško