Inflammation is a complex process frequently associated with pain and fever, involving increased vascular permeability, increased protein denaturation and alteration of the membrane. The clinical symptoms such as fever, aches and pains associated with several diseases are directly or indirectly due to inflammatory disorders. Most biological proteins lose their biological activities or functions when denatured. This work studies the anti-inflammatory and antioxidant performance of flavonoid-rich extract of Buchholzia coriacea seed. The in vitro anti-inflammatory studies for the extract were done using protease inhibition activity, membrane stabilization and albumin denaturation inhibition assays, and antioxidant activities were performed by determination of hydrogen peroxide (H₂O₂), nitric oxide (NO), and 2-2-diphnyl-1-picrylhydrazyl (DPPH) scavenging activity assays as well as total antioxidant capacity. The ethanol flavonoid-rich extract of B. coriacea seed was effective in inhibiting the denaturation of albumin in a concentration-dependent manner. The inhibitory ability of the extract on protease increased significantly (p < 0.05) with increased concentration. The flavonoid-rich extract of the seeds of B. coriacea like indomethacin significantly (p < 0.05) protected the human erythrocyte membrane against lyses induced by hypotonic solution when compared to the control. The plant extract at different concentrations inhibited significantly (p ˂ 0.05) oxidative stress caused by H₂O₂, DPPH, NO radicals when compared to the control. The flavonoid-rich extract was found to possess radical scavenging and anti-inflammatory activities as determined by albumin denaturation, protease inhibition, membrane stabilization, hydrogen peroxides (H₂O₂) 2,2-Diphenyl-1-picrylhydrazyl (DPPH), Nitric oxide (NO) radical scavenging activities and total antioxidant capacity data. Further research on isolating, purifying and characterizing the particular class of flavonoids responsible for the aforementioned activities may be undertaken, and they may be incorporated into existing anti-inflammatory herbal compositions to improve their efficacy.