Surgical site infections (SSI) are one of the main healthcare-related infections in developing nations. Regardless of upgrades in surgical strategy and the utilization of best disease avoidance techniques, SSI stayed the significant reason for medical clinic obtained infections. Subsequently, the target of this paper was to describe risk factors for SSI and the utilization of antibiotics to decrease the risk involved for the SSI. SSI is a possibly morbid and expensive intricacy of medical procedure. In this way, an underlying pursuit recognized various titles distributed in 2012-2022. Extracted data including design of study and procedure, revealed combined occurrence and time taken as post-surgery until the beginning of SSI, and probabilities proportions and associated inconstancy for all variables considered in univariate and additionally multivariable investigations. In a wide survey of available works, risk factors for SSI were portrayed as depicting decreased wellness, patient fragility, medical procedure length, and intricacy. The occurrence of SSI was high in the review set. There were critical quantities of contributing variables to the event of surgical site infections. Recognition of risk factors habitually connected with SSI considers the identification of such patients with the best requirement for ideal protective actions to be recognized and pre-treatment before medical procedure.