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Stereoselective Synthesis of Thiaerythrinanes via Parham Cyclisation
Published:
30 November 2007
by MDPI
in The 11th International Electronic Conference on Synthetic Organic Chemistry
session General Organic Synthesis
Abstract: Parham cyclisation – intermolecular α-amidoalkylation sequence constitute a route to trans thiazolo[4,3-a]isoquinolinones. These thiazolidindiones, that incorporate allyl groups at C-1 and C-10b, are efficient precursors of thiaerythrinanes by ring-closing methathesis reactions.
Keywords: Lithiation, lithium-halogen exchange, α-amidoalkylation, Parham cyclisation, heterocycles, thiareythrinanes
