Metal complexes are widely used in pharmaceutics, cosmetics, electronics, casting printing, and power generation. One of the major challenges due to their long-term use as medicines is their accumulation in the body. This issue needs to be resolved to avail better results of metal complexes as medicines. The use of metal-nanoparticles(MNPs) can be expected to reduce the toxicity of metal and their accumulation in the body. The aim of this paper is to give an insight about the variation induced in the cytotoxic activity of MNP-ligand complexes by replacing respecting heavy metals with their nanoparticles(NPs).