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Synthesis of Aromatic Macrodiolides and Study of Their Antitumor Activity In Vitro
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Academic Editor: Julio A. Seijas
Published:
15 November 2023
by MDPI
in The 27th International Electronic Conference on Synthetic Organic Chemistry
session Bioorganic, Medicinal and Natural Products Chemistry
Abstract:
Based on (5Z,9Z)-tetradeca-5,9-diene-1,14-dioic acid previously undescribed polyether aromatic macrodiolides were synthesized in good yields (53-67%). The cytotoxicity of the resulting macrocyclic compounds in vitro against tumor Jurkat, K562, conditionally normal Hek293 cell lines and normal fibroblasts was assessment carried out. The ability of the most active macrodiolide to induce apoptosis towards Jurkat cells and influence the cell cycle was studied.
Keywords: 1,5-Dienoic compounds; homo-cyclomagnesiation; Grignard reagents; Macrodiolides; Crown ether
