Thiophene is a five membered sulfur containing hetero aromatic ring. Its presence in compounds of therapeutic interest is remarkable, leading to various research to develop strategies to synthesize new biologically active thiophene analogues. Among the biological activities described in litterature: anti-inflammatory, anti-tumor, anti-Alzheimer, antiviral, ...etc. A series of thiophene compounds can be synthesized through various routes with pharmacological activities.

Vilsmeier-Haack is a great reagent known by its multiple uses in organic chemistry. This reagent is widely used for chloroformytation of ketones giving β-chloroacroleïnes ; scaffolds to prepare 5-aryl-2-acetylthiophenes derivatives ; the ketone fonction in position 2 offers various interesting reactions.

Our team aims to develop and functionalize heterocyclic compounds with promising biological and pharmacological activities including some new concept of green chemistry; as a part of our research, different derivatives of 5-aryl-2-acetylthiophenes were achieved in good yields that are used then to prepare new compounds.