The aim of this study is to synthesis of pyrrole derivatives based on phenacyl bromide and amine, which is promoted by a green and heterogeneous chitosan-based catalyst under optimal laboratory conditions through the multi-component reaction strategy namely Hantzsch pyrrole synthesis. This bio-based CS-EDTA-THEIC network contains appropriate basic and acidic active sites to act as a multifunctional catalyst. Indeed, the CS-EDTA-THEIC nanomaterial used in the multicomponent reaction for synthesis of pyrrole derivatives showed excellent yields in short reaction times. Furthermore, the CS-EDTA-THEIC network, as a heterogeneous catalyst, illustrated magnificent reusability and can be used at least six times without significant loss of its activity.
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Synthesis of pyrrole derivatives through multicomponent reaction strategy in the presence of new heterogeneous catalyst based on chitosan
Published:
28 November 2023
by MDPI
in The 27th International Electronic Conference on Synthetic Organic Chemistry
session Polymer and Supramolecular Chemistry
https://doi.org/10.3390/ecsoc-27-16361
(registering DOI)
Abstract:
Keywords: Pyrrole derivatives; Chitosan-Based catalyst; multi-component reaction (MCR) strategy; multifunctional heterogeneous catalyst; Green chemistry.
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