A new approach to synthesis of 2-carbamoylbenzothiazoles

V. Yarovenko; F. Stoyanovich; O. Zolotarskaya; I. Zavarzin; M. Krayushkin

doi:10.3390/ecsoc-2-01678

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A new approach to synthesis of 2-carbamoylbenzothiazoles

V. N. Yarovenko

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F. M. Stoyanovich

O. Yu. Zolotarskaya

I. V. Zavarzin

M. M. Krayushkin

¹ N.D.Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 117913 Moscow, Russian Federation.

Published: 01 November 1998 by MDPI in The 2nd International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-2-01678

Abstract: The reactions of substituted anilines with chloroacetamide and sulfur in the presence of triethylamine afford monothiooxamides, which being treated with K3Fe(CN)6 are cyclized to 2-carbamoylbenzothiazoles. The cyclization is established to be accompanied by the formation of the corresponding thiooxanilic acids, which are also cyclized to benzothiazole-2-carboxylic acids.

Keywords: Anilines, chloroacetamides, sulfur, monothiooxamides, 2-carbamoylbenzothiazoles, thiooxanilic acids, benzothiazole-2-carboxylic acids.

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V. Yarovenko

F. Stoyanovich

O. Zolotarskaya

I. Zavarzin

M. Krayushkin