Synthetic Active Site Analogues of Heme-Thiolate Proteins Catalysis and Identification of Elusive Intermediates

W. Woggon; H. Aissaoui; R. Bachmann; C. Claude; A. Schweiger; H. Wagenknecht

doi:10.3390/ecsoc-2-01694

Previous Article in event

A Chemical Synthesis of Porphobilinogen Imitating the Pathway Proposed by Shemin for the Biosynthesis: Comparing Inhibition Studies with Investigations of Chemical Reactivity

Next Article in event

Synthesis of Some 2,6-Disubstituted 4-Pyridinecarboxamides and -Carbothioamides, and Their Antimycobacterial and Photosynthesis-Inhibiting Activity

Synthetic Active Site Analogues of Heme-Thiolate Proteins Catalysis and Identification of Elusive Intermediates

W. D. Woggon

^{*

1},

H. Aissaoui

¹,

R. Bachmann

²,

C. Claude

¹,

A. Schweiger

²,

H. A. Wagenknecht

¹ Institut für Organische Chemie der Universität Basel, St. Johanns- Ring 19, CH-4056 Basel, Switzerland
² Laboratorium für Physikalische Chemie, Eidgenössische Technische Hochschule, CH-8092 Zürich

Published: 01 November 1998 by MDPI in The 2nd International Electronic Conference on Synthetic Organic Chemistry session Medicinal and Bioorganic Application of Organic Synthesis

https://doi.org/10.3390/ecsoc-2-01694

Abstract: Intermediates of the catalytic cycles of chloroperoxidase and cytochrome P450cam are identified and characterized by means of synthetic enzyme models.

Keywords: chloroperoxidase · chlorination · cytochrome P450 . enzyme model · EPR-ENDOR-spectroscopy . heme-thiolate protein · iron porphyrin

View paper

25 Reads
0 Recommendations

W. Woggon

H. Aissaoui

R. Bachmann

C. Claude

A. Schweiger

H. Wagenknecht