Phthalides and Chromones from 4-Coumarinacetic acids, Study of Beneficial Effects of Microwave Irradiation on Synthesis.

Margita Lacova; Dusan Loos; Jarmila Chovancova; Katarina Kralova

doi:10.3390/ecsoc-3-01750

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A New Route for the Synthesis of Cyclic Thioureas and Related Compounds

Phthalides and Chromones from 4-Coumarinacetic acids, Study of Beneficial Effects of Microwave Irradiation on Synthesis.

Margita Lacova

^{*

1},

Dusan Loos

²,

Jarmila Chovancova

¹,

Katarina Kralova

¹ Department of Organic Chemistry, Comenius University, Mlynska dolina CH-2, SK- 842 15 Bratislava, Slovakia
² Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynska dolina CH-2, SK-842 15 Bratislava

Published: 01 November 1999 by MDPI in The 3rd International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-3-01750

Abstract: 3-(4-Coumarinylmethylene)phthalides and 2-, or 3-(4-coumarinylethenyl)-4-chromones were prepared by condensation reaction. Beneficial effect of microwave irradiation on length of reaction time was investigated. Some subsequent reactions of these derivatives with nucleophiles are described. Nucleophile attack is studied by AM1 theoretical method.

Keywords: 3-formylchromones, dicarboxylic acid anhydrides, condensation reaction, pyridine derivatives

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Margita Lacova

Dusan Loos

Jarmila Chovancova

Katarina Kralova