Coupling of Phenols to 2-Chlorotrityl Resins under Non-basic Conditions

Bernd Renneberg; Werner Breitenstein

doi:10.3390/ecsoc-3-01760

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Coupling of Phenols to 2-Chlorotrityl Resins under Non-basic Conditions

Bernd Renneberg

^{*

1},

Werner Breitenstein

¹ Argonaut Technologies AG, P.O. Box 43, CH-4132 Muttenz 2, Switzerland
² Combinatorial Chemistry Unit, Core Technology Area, Novartis Pharma Inc., CH-4002 Basel, Switzerland

Published: 01 November 1999 by MDPI in The 3rd International Electronic Conference on Synthetic Organic Chemistry session Combinatorial Synthesis, Parallel Synthesis and Automation

https://doi.org/10.3390/ecsoc-3-01760

Abstract: A new procedure for the coupling of phenols to 2-chlorotrityl resins has been developed using polymer bound 2-pyridyl ether derivative 1 as tritylation agent. The method allows the immobilisation of phenols under non-basic conditions and is particularly suited for base sensitive phenolic compounds. Scope and limitation of this new coupling method have been investigated.

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Bernd Renneberg

Werner Breitenstein