Synthesis of Glycosyl Phosphoramidates: Novel Isosteric Analogs of Glycosyl Phosphates

Thanukrishnan Kannan; Subramaniam Vinodhkumar; Duraikkannu Loganathan

doi:10.3390/ecsoc-3-01768

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Synthesis of Glycosyl Phosphoramidates: Novel Isosteric Analogs of Glycosyl Phosphates

Thanukrishnan Kannan

^*,

Subramaniam Vinodhkumar

Duraikkannu Loganathan

¹ Indian Institute of Technology Madras, Chennai-600 036, India

Published: 01 November 1999 by MDPI in The 3rd International Electronic Conference on Synthetic Organic Chemistry session Medicinal and Bioorganic Application of Organic Synthesis

https://doi.org/10.3390/ecsoc-3-01768

Abstract: Several glycosyl phosphoramidates, which are novel isosteric analogs of glycosyl phosphates, were synthesized in four steps starting from the free sugars, the key step being the Staudinger reaction of fully acetylated b -D-glycosyl azide with trimethyl phosphite.

Keywords: Glycosyl phosphoramidates, Isosteric analogs, Staudinger reaction.

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Thanukrishnan Kannan

Subramaniam Vinodhkumar

Duraikkannu Loganathan