Abstract: Quinaldine derivatives were obtained, some of them by means of novel synthetic methods. All the compounds were tested for their antifungal activity. The synthetic approach, analytical and spectroscopic data of all newly synthesized compounds are presented. Structure-activity relationships among the chemical structure, the physical properties and the biological activity of the evaluated compounds are discussed. Brome derivatives of 2-methylquinolin-8-ol possessed the highest antifungal activity against all evaluated fungal strains.