Efforts are being made to valorize agroindustrial waste by recovering compounds of technological or functional interest using green extraction methods. Natural deep eutectic solvents (NADESs) emerge as a versatile and sustainable alternative to traditional organic solvents. The objective was to design food-safe NADESs and use them as solvents to extract polyphenolic compounds from plant sources. NADESs were prepared as mixtures of citric acid and glucose (1:1) (CIT:GLU) and with glycerol and glucose (4:1) (GLI:GLU), with a final aqueous content of 30%w/v. The mixtures were heated and stirred (60 °C, 90 min) until homogeneous systems were obtained and were characterized by determining their density, refractive index, pH, water activity (a_w), electrical conductivity, and polarity. The NADES extraction yields were determined based on the total polyphenolic content (TPC) extracted per gram of dry Moringa oleifera leaf. The prepared NADESs had a density between 1,238 and 1,382 g/mL, with systems CIT:GLU presenting a higher density than GLI:GLU. The refractive indices ranged from 1,420 to 1,456 without significant differences (p<0.05) between the systems. The a_w of the CIT:GLU NADES was close to 0.75 and 0.66 for the GLI:GLU mixture, suggesting a greater water--water interaction in this last system. The pH of NADESs with citric acid was less than 1.00 due to the high concentration of acid, while the pH in the GLI:GLU system was 3.13. Conductivity was 0.31 mS/cm in CIT:GLU due to the presence of citrate and null in the GLI:GLU, since its components do not form ions. The TPC of the extracts was between 40 and 50 mg EAG/g b.s. The extraction yields were compared with ethanol, and better yields were obtained for the NADESs. In addition, NADESs have the advantage of being natural, non-toxic, and can be designed with particular characteristics to favor the extraction of specific compounds, and also to stabilize them during extraction and storage.