The integration of Artificial Intelligence (AI) and telemedicine is transforming pediatric healthcare management, presenting unprecedented opportunities for improving the quality, accessibility, and efficiency of care. This review explores how these technologies impact pediatric healthcare, focusing on diagnostic accuracy, treatment personalization, and patient monitoring. AI-driven tools, including machine learning algorithms and natural language processing, enhance early diagnosis and intervention by analyzing vast datasets to identify patterns indicative of pediatric diseases. These tools support clinicians in making more informed decisions, reducing diagnostic errors and improving outcomes. Telemedicine, facilitated by advancements in communication technologies, extends the reach of pediatric care to remote and underserved areas, ensuring timely medical attention. Virtual consultations and remote monitoring enable continuous care for chronic conditions, reducing hospital visits and minimizing the risk of exposure to infectious diseases. Telemedicine also fosters better patient and family engagement, providing education and support through digital platforms. The synergy of AI and telemedicine offers a comprehensive approach to pediatric healthcare, combining both technologies' strengths to deliver personalized and proactive care. AI algorithms can process real-time data from telemedicine consultations, refining treatment plans and predicting potential health issues before they escalate. This integrated approach enhances clinical outcomes and optimizes resource allocation, reducing healthcare costs. India's eSanjeevani telemedicine platform, which has served over 241 million patients through more than 122,000 Health and Wellness Centers, exemplifies this integration. It ensures that specialized care reaches remote and underserved areas, improving clinical outcomes and optimizing resource allocation. Despite the promising benefits, challenges such as data privacy, algorithmic bias, and the need for robust regulatory frameworks must be addressed to ensure these technologies' safe and ethical implementation. This review highlights the critical role of AI and telemedicine in revolutionizing pediatric healthcare, underscoring the importance of continued research, collaboration, and policy development to fully realize their potential in improving children's health and well-being.