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Bisbenzamidines as antifungal agents. Are both amidines functions required to observe an anti-Pneumocystis carinii activity?
Jean Jacques Vanden Eynde
* 1 ,
El- Mouktar Aliouat
2, 3 ,
Muriel Pottier
2 ,
Eduardo Dei-Cas
2, 3 ,
Tien L. Huang
4 ,
Dimitri Stanicki
1 ,
Julien Laurent
1
1  University of Mons, Laboratory of Organic Chemistry, Faculty of Sciences, Mons, Belgique
2  University of Lille 2, Laboratory of Parasitology, Faculty of Pharmacy, Lille, France
3  Pasteur Institute of Lille, Laboratory of Parasitism Ecology, Lille, France
4  Xavier University of Louisiana, College of Pharmacy, Division of Basic Pharmaceutical Sciences, New Orleans, USA
Published: 01 November 2009 by MDPI in The 13th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural Products
https://doi.org/10.3390/ecsoc-13-00208
Abstract: A library of 19 novel 4-(4-phenylpiperazine-1-yl)benzamidines has been synthesized and evaluated in vitro against Pneumocystis carinii. Among these compounds, N-ethyl and Nhexyl 4-(4-phenylpiperazine-1-yl)benzamidines emerged as the most promising compounds with inhibition percentages at 0.1μg/ml of 61(percent) and 56(percent) respectively.
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