Abstract: Background: Abelmoschus esculentus L. Malvaceae is used for a long time as a daily food in many countries because of its nourishing components. Extracts from Abelmoschus esculentus have been known to ameliorate not only hyperglycemia but also hyperlipidemia in diabetic mice induced by alloxan and streptozocin. However, its hypolipidemic activity has not yet been studied clearly. Objective: Hypolipidemic activity of the extracts from total plant by dichloromethan (AE1), methanol (AE2) and from fruit by dichloromethan (AE3) and methanol (AE4) was studied and compared to that of simvastatin (Zocor®). Methods: Hyperlipidemia in mice was induced by single intra-peritoneal injection of 300 mg/kg of Tyloxapol. Studied extracts were orally administered at dose equivalent to 30g of dry extract/kg immediately after Tyloxapol injection. Results: Cholesterol levels decreased 56.45(percent), 55.65(percent), 41.13(percent), 40.50(percent) and 53.63(percent) respectively in groups orally administered AE1, AE2, AE3, AE4 and simvastatin as compared to the tyloxapol injected group. Triglycerids levels in treated groups had no significant difference as compared to simvastatine group except methanolic extract from fruit (AE4) administered group. Conclusion: Abelmoschus esculentus is also useful in diminishing cholesterol and triglycerids levels in hyperlipidemic mice.