Retinoblastoma (RB) is a rare pediatric retinal cancer. Due to financial and medical limitations, many children with retinablastoma (RB) only receive therapy when the disease has progressed to the metaphase and advanced clinical stages, which increases the risk of blindness and impairment. Despite the fact that there are numerous methods for treating RB, some children do not respond well to treatment for a variety of reasons. Natural medicines produced from plants are frequently employed in the research of RB and have demonstrated clear therapeutic effects in the treatment of a variety of malignancies. In order to offer suggestions for the clinical usage of these medications as well as the creation of novel therapeutic pharmaceuticals, we examine natural compounds produced from plants that are employed in the investigation of anti-RB.

RB research makes substantial use of natural chemicals derived from plants, which have shown promising therapeutic advantages in the treatment of many cancers. To provide recommendations for the clinical application of these drugs and the development of new therapeutic drugs, we analyze natural chemicals derived from plants that are used in anti-RB research. It has also been demonstrated that certain naturally occurring chemicals, in addition to conventional anticancer medications, are useful in treating RB. These consist of sterol derivatives (such as ursolic and oleanolic acid), naphthoquinones (such as β-lapachone), and catechol derivatives (such as curcumin). Our main objective is to explore natural novel therapeutics for RB and make use of these natural active moiety in the formulation of the development of a nano drug delivery system.