- Overview:
A global health concern is neurodegenerative illnesses, which are brought on by increasing loss of the neurons, one of the main causes of cognitive and physical deterioration in these illnesses. The death of brain cells or nervous system cells is the cause of this neurological loss. Huntington's disease, Parkinson's disease, and Alzheimer's disease are among the most common conditions that share protein misfolding and aggregation. According to a WHO news report, neurological disorders impact more than one in three people and are a leading cause of disability worldwide. Since 1990, the DALYs (Disability-Adjusted Life Years) for these illnesses have gone up by 18%. The prevalence of Alzheimer's disease is estimated to be 55 million people worldwide, and for Parkinson's disease, it is 10 million globally.
Objective
We wished to achieve the following:
To review and research protein misfolding and aggregation's role in neurodegenerative diseases.
To find common molecular mechanisms for neurological disorders and the target sites for a therapeutic effect.
To evaluate the effect of genetic, environmental, and lifestyle choices on protein misfolding.
Methods
A thorough search of the literature was conducted in several large medical databases. This study was carried out in the form of a meta-analysis of the available literature.
Key findings on protein misfolding and aggregation, the participant characteristics, and the study design were all included in the data extraction process. The data analysis was performed, and the results were presented.
Results
We determined common pathways and sites for protein misfolding in neurodegenerative disorders. The results reflect upon the different factors affecting the aggregation and misfolding of proteins, and using them, the target sites for a therapeutic effect can be confirmed.
