Abstract: Nitrogen heterocycles are a part of a special group of organic substances due to its many applications in the pharmaceutical market, exist a large number of structures carrying nitrogenous substances. Among these heterocycles the isoxazoles and tetrahydroquinolines (THQs)1 have shown significant biological activity on different therapeutic targets. They show several applications in diverse areas such as pharmaceuticals, agrochemistry, and industry.2 They are also found in natural sources showing insecticidal, plant growth regulation, and pigment functions.3 Within the field of activity of the heterocycles is found the antibacterial activity, which has had a growing interest because the inappropriated use of antibiotic has increased the resistance of bacterial to the commercial antibiotics, even the appearance of bacterial strain with no treatment knows.4 Similarly, the emergence of antibiotic resistance in some bacterial populations is yet a relevant field of study in some areas of Science included the organic chemistry.Due to mentioned previously, the THQs e isoxazole compounds have been considered a good starting material for the search of novel antimicrobial agents, therefore we include them in this research.Isoxazoles derivatives were synthesized by 1,3 dipolar cycloaddition and a serie of tetrahydroquinolines derivatives were synthesized by Povarov reaction, these compounds were purified by conventional chromatographic techniques and characterized spectroscopically. Antibacterial activity was assessed by spectrophotometric measurements, determining the MIC for each compound against the four bacterial, Escherichia coli, Pseudomona aeruginosa, Staphylococcus aureus and Acinetobacter baumannii.