Climate change in urban areas is not neutral concerning different social groups and vulnerable people. People such as the elderly or people with disabilities are more exposed in terms of vulnerability than the rest of the population simply because they are less mobile. This is not the only aspect to be taken into account; in fact, the vulnerabilities mentioned above are often linked to situations of chronic illness, low social income, and potential situations of energy poverty, which prevent de facto protection from heat waves, at least in one's own home. The protection of those beyond the limits of the average individual is, therefore, a major social and economic challenge in a system of "advanced countries" in which the demographic pyramid of the young population is shrinking and that of the elderly is growing considerably, which is also thanks to developments in medicine and quality of life. The first results of the European CARMINE project are presented, which, in a specific study area (the metropolitan city of Bologna, Italy), aimed to study the mobility pathways of these frailties to reach potential markets and to identify the NBS that could potentially be used along the highlighted pathways to protect the physiological balance of these sectors of the urban population.