Inula viscosa, which is also known as false yellow head or sticky fleabane, is a flowering plant with powerful potential. Traditionally, this plant was used in phytomedicine due to its significant properties like anti-inflammatory, antiseptic, and antioxidant activities. Consequently, a rotary evaporator was employed to get the aqueous crude extract of this plant, utilizing distilled water as the extraction medium. Total phenolic, flavonoids, and tannin content and DPPH radical scavenging activity were examined to assess the antioxidant ability in the extract. Volatile components found in the Inula viscosa essential oil were analyzed with the help of GC-MS after hydro distillation extraction. A cream was prepared containing 5% aqueous crude extract and 2% essential oil from the Inula viscosa plant, where these two components have synergetic effects, producing the best results. An incision was made on 9 mice, and they were split into 3 groups: the control group receiving only the cream base on the wound, and the two other groups being administered treatment of Fucidin or Inula viscosa cream, respectively. Results showed that the Inula viscosa cream significantly aided in diminishing the wound area, achieving closure and appropriate healing in a shorter period without any complications. Hence, Inula viscosa cream has proven to have powerful wound healing capabilities.