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Synthesis of novel (±)-cis-exo-norbornane amino acid containing cyclic hexapeptide: Analogue of Dolastatin 16
Published:
30 October 2015
by MDPI
in The 19th International Electronic Conference on Synthetic Organic Chemistry
session General Organic Synthesis
Abstract:
Novel cyclohexapeptide has been synthesized by replacing the unusual amino acids (dolaphenvaline and dolaphenleuine) of dolastatin 16 with (±)-cis-exo-norbarnane and phenyl alanine amino acids. Novel cyclic hexapeptide alongwith dimers, tetramers composed of alternating L-proline subunits have been synthesized in solution phase and well characterized.
Keywords: Dolastatin 16, exo-norbornane amino acid, peptide synthesis, cyclic hexapeptide.
