Monitoring of mechanical structures is a Big Data challenge and includes Structural Health Monitoring (SHM) and Non-destructive Testing (NDT). The sensor data produced by common measuring techniques, e.g., guided wave propagation analysis, is characterized by a high dimensionality in the temporal and spatial domain. There are off- and on-line methods applied at maintenance- or run-time, respectively. On-line methods (SHM) usually are constrained by low-resource processing platforms, sensor noise, unreliability, and real-time operation requiring advanced and efficient sensor data processing. Commonly, structural monitoring is a task that maps high-dimensional input data on low-dimensional output  data (information, that is feature extraction), e.g., in the simplest case a Boolean output variable “Damaged”. Machine Learning (ML), e.g., supervised learning, can be used to derive such a mapping function. But ML quality and performance depends strongly on the input data size. Therefore, adaptive and reliable input data reduction (that is feature selection) is required at the first layer of an automatic structural monitoring system. Assuming some kind of two-dimensional sensor data (or n-dimensional data in general), image segmentation can be used to identify Regions of Interest (ROI), e.g., of wave propagation fields. Wave propagation in materials underlie reflections that must be distinguished, especially in hybrid materials (e.g., combining metal and fibre-plastic composites) there are complex wave propagation fields.  The image segmentation is one of the most crucial part of image processing (Mishra, 2011). Major difficulties in image segmentation are noise and the differing homogeneity (fuzziness and signal gradients) of regions, complicating the definition of suitable threshold conditions for the edge detection or region splitting/clustering. Many traditional image segmentation algorithms are constrained by this issue. Artificial Intelligence can aid to overcome this limitation by using autonomous agents as an adaptive and self-organizing software architecture, presented in this work. Using a collection of co-operating agents decomposes a large and complex problem in smaller and simpler problems with a Divide-and-Conquer approach. Related to the image segmentation scenario, agents are working mostly autonomous (de-coupled) on dynamic bounded data from different regions of an image (i.e., distributed with simulated mobility), adapted to the locality, being reliable and less sensitive to noisy sensor data. In this work, different agent behaviour and segmentation approaches are introduced and evaluated with measured high-dimensional data from piezo-electric acusto-ultrasonic sensors recording wave propagation in plate-like structures. Commonly, SHM deploys only a small set of sensors and actuators at static positions delivering only a few temporal resolved sensor signals (1D), whereas NDT methods additionally can use spatial scanning to create images of wave signals (2D). Both one-dimensional temporal  and two-dimensional spatial segmentation is considered to find characteristic ROIs.