Solvent free synthesis of imidazo [1,2-a] pyridin- tetrazolo [1,5-a] quinolones via a IMCR one-pot process.

Mahanandaiah Kurva; Murali Venkata Basavanag Unnamatla; María del Rocio Gámez Montaño

doi:10.3390/ecsoc-22-05796

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Solvent free synthesis of imidazo [1,2-a] pyridin- tetrazolo [1,5-a] quinolones via a IMCR one-pot process.

Mahanandaiah Kurva

Murali Venkata Basavanag Unnamatla

María del Rocio Gámez Montaño

¹ Universidad de Guanajuato, División de Ciencias Naturales y Exactas, Departamento de Química

Published: 14 November 2018 by MDPI in The 22nd International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-22-05796

Abstract:

Solvent-catalyst free synthesis of poly-heterocycles containing imidazo[1,2-a]pyridine and Tetrazolo[1,5-a]quinoline frameworks via a one-pot process: IMCR Groebke-Blackburn-Bienaymé reaction (GBBR)/S_NAr/ ring-chain azido tautomerization under ecofriendly conditions. The Tetrazolo[1,5-a]quinoline and imidazo [1,2-a] pyridine scaffolds are the structural core of various compounds with interesting pharmacological properties and could lead to the discovery of novel bioactive molecules.

Keywords: Isocyanide based multicomponent reactions; Groebke-Blackburn-Bienaymé reaction; Tetrazolo [1,5-a] quinolines; ring-chain azido tautomerization; one-pot process.

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Mahanandaiah Kurva

Murali Venkata Basavanag Unnamatla

María del Rocio Gámez Montaño