Preparation and Herbicidal Properties of Ring-Substituted 4-Chloro-2-styrylquinazolines

Jaroslaw Polanski; Jacek Finster; Wioleta Kowalczyk; Katarina Kralova; Matus Pesko; Josef Jampilek; Robert Musiol

doi:10.3390/ecsoc-15-00586

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Preparation and Herbicidal Properties of Substituted Quinoline-2-carboxanilides

Preparation and Herbicidal Properties of Ring-Substituted 4-Chloro-2-styrylquinazolines

Jaroslaw Polanski

¹,

Jacek Finster

¹,

Wioleta Kowalczyk

¹,

Katarina Kralova

²,

Matus Pesko

³,

Josef Jampilek

⁴,

Robert Musiol

^{*

1}

¹ Institute of Chemistry, University of Silesia, Szkolna 9; 40-007, Katowice Poland
² Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynska dolina Ch-2, 84215 Bratislava, Slovakia
³ Department of Ecosozology and Physiotactics, Faculty of Natural Sciences, Comenius University, Mlynska dolina Ch-2, 84215 Bratislava, Slovakia
⁴ Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 61242 Brno, Czech Republic

Published: 27 October 2011 by MDPI in The 15th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic, Medicinal and Natural Products

https://doi.org/10.3390/ecsoc-15-00586

Abstract: In this study, a series of new seven ring-substituted 4-chloro-2-styrylquinazoline derivatives were prepared. The procedures for synthesis of the compounds are presented. The compounds were analyzed using RP-HPLC to determine lipophilicity. They were tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. For all the compounds, the relationships between the lipophilicity and the chemical structure of the studied compounds are discussed, as well as their structure-activity relationships (SAR).

Keywords: 4-chloro-2-styrylquinazoline derivatives; Lipophilicity; PET inhibition; Spinach chloroplasts; Structure-activity relationships

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