The antioxidant potential of phenolic compounds has been extensively investigated because oxidative stress is a hallmark of a variety of human diseases. In this study, we demonstrated antioxidant activity of the molecular hybrids compounds of di-tert-butylphenolic betacalcogenamine in 1,1-diphenyl-2-picryl-hydrazyl (DPPH^•+), 2,2’-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS⁺) radicals scavenging, and ferric ion reducing antioxidant power (FRAP) assays. The compounds N-cyclohexyl-2-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(N-(2-(phenyltellanyl)ethyl)acetamido)acetamide, and N-(tert-butyl)-2-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(N-(2-(phenyltellanyl)ethyl)acetamido)acetamide were diluted in dimethylsulfoxide (DMSO) and tested at 0.1 µM, 1 µM, 10 µM, 50 µM and 100 µM concentrations. All in vitro analyses were performed in triplicates and statistically analyzed using one-way ANOVA followed by Tukey’s pos hoc test. Data were presented as mean ± standard error of the mean (SEM), and the statistical significance level was set at p < 0.05. In addition, maximum inhibition (I_Máx) and the half maximal inhibitory concentration (IC₅₀) were calculated. Our data revealed that both compounds had radical scavenging efficiency in the DPPH^•+, and ABTS⁺ assays when compared to control. In addition, in the FRAP assay, the compounds exhibited ferric-reducing ability when compared to control, reinforcing the previous results. These findings show that molecular hybrids compounds of di-tert-butylphenolic betacalcogenamine containing tellurium are promising targets for further studies regarding their antioxidant potential in the treatment of pathophysiology related to oxidative impairment.