A new approach to 7-amino-4-oxo-4,5-dihydro-3H-pyrano[2,3-d]pyrimidine-6-carbonitriles

¹ Kuban State University
² Department of Organic Chemistry and Technologies, Kuban State University, 149 Stavropolskaya Str., 350040 Krasnodar, Russia
³ ChemEx Lab, Vladimir Dal’ Lugansk National University
⁴ North Caucasus Federal University

Published: 13 November 2020 by MDPI in The 24th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-24-08105

Abstract:

S-alkyl derivatives of thiobarbituric acid easily react with arylmethylene malononitriles in the presence of base to give new 7-amino-4-oxo-4,5-dihydro-3H-pyrano[2,3-d]pyrimidine-6-carbonitriles. The structure of products and the mechanism of formation are discussed.

Keywords: Thiobarbituric acid, malononitrile, 2-amino-4H-pyran-3-carbonitriles, Michael addition, heterocycliaztion

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