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On the acylation of 1,6-diamino-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles
Published:
14 November 2020
by MDPI
in The 24th International Electronic Conference on Synthetic Organic Chemistry
session General Organic Synthesis
Abstract:
1,6-Diamino-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles, prepared by reaction of cyanoacethydrazide with arylmethylene malononitriles, react with 1-cyanoacetyl-3,5-dimethylpyrazole and chloroacetyl chloride to give corresponding cyanoacetamides and chloroacetamides. The reaction with phthalic anhydride proceed under harsh conditions to give 4,7-dioxo-4,7-dihydropyrido[1',2':2,3][1,2,4]triazolo[5,1-a]isoindole-1,3-dicarbonitriles.
Keywords: cyanoacethydrazide, N-aminopyridines, cyanoacetylation, heterocyclization
