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1’-Homocarbocyclic Nucleoside Analogues with an Optically Active Substituted Bicyclo[2.2.1]Heptane Scaffold
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Published:
14 November 2020
by MDPI
in The 24th International Electronic Conference on Synthetic Organic Chemistry
session General Organic Synthesis
Abstract:
An optically active bicyclo[2.2.0]heptane fragment was introduced in the molecule of new 1’-homonucleosides on a 2- 6-chloro-amino-purine scaffold to obtain 6-substituted carbocicloc nucleozide analogues as antiviral compounds. The synthesis was realized by a Mitsunobu reaction of the base with the corresponding bicyclo[2.2.0]heptane intermediate ant then the nucleoside analogues were obtained by substitution of the 6-chlorime with selected pharmaceutically accepted amines. A molecular docking study of the compounds on influenza, HSV and low active Coronavirus was realized. Experimental screening of the compounds on the same viruses are developing and soon will be finished.
Keywords: Carbocycli nucleosides, Mitsunobu reaction, bicyclo[2.2.0]heptane scafold; molecular docking, antiviral activity
