Synthesis of Epoxyisoindolinones Via Microwave-assisted Ugi-4C/Intramolecular-Diels-Alder Reaction

Fernando Torres Hernández; Rocío Gámez-Montaño

doi:10.3390/ecsoc-24-08425

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Synthesis of Epoxyisoindolinones Via Microwave-assisted Ugi-4C/Intramolecular-Diels-Alder Reaction

Fernando Torres Hernández

Rocío Gámez-Montaño

¹ Universidad de Guanajuato

Published: 14 November 2020 by MDPI in The 24th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-24-08425

Abstract:

A series of Epoxyisoindolinones were synthesized by microwave-assisted domino Ugi-4C/Intramolecular-Diels-Alder (U-4C/IMDA) under eco-friendly conditions (free solvent, free catalyst, short time) and using orthogonal-bifunctional components. Epoxyisoindolinones are a privileged core of high interest in medicinal chemistry mainly for its anticancer activity in several cell lines.

Keywords: multicomponent reactions; Ugi, Diels-alder, Epoxyisoindolinone

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Fernando Torres Hernández

Rocío Gámez-Montaño