Multi-target Design, Synthesis and Study of a Selected Series of Carbamates and Esters with Coumarin Scaffold

Developed countries\' society face, with the increase of the population life expectancy, a major problem related with neurodegenerative diseases (ND), such as Parkinson\'s and Alzheimer\'s diseases. Therefore, a need for new drugs targeting these diseases emerges. Some of the few accessible treatments use monoamine oxidases inhibitors (MAOI-A and MAOI-B) and acetylcholinesterase inhibitors (AChEI). Coumarins are a large family of compounds of natural and/or synthetic origin that proved to have numerous pharmacological properties. In this study, we developed new synthetic methodologies to create novel multi-target inhibitors focused on the coumarin scaffold. Following this work, docking studies of the previously prepared compounds are currently in progress. Some preliminary results are presented in this communication.