MINIATURIZED AND RAPID ELECTROCHEMICAL IMMUNOSENSOR FOR THE DETECTION OF TUBERCULOSIS BASED ON SCREEN-PRINTED CARBON ELECTRODES

Tuberculosis (TB) is one of those diseases that can affect a huge number of people on a global scale. In many regions, the lack of speedy TB diagnosis is responsible for its propagation. Analyzing, testing, and early diagnosis can contain TB-causative bacterium, Mycobacterium tuberculosis (Mtb). Biosensing is the deck that allows rapid, sensitive, and selective detection which in turn can serve the purpose for rapid and precise detection of TB. In our work, based on miniaturized sensing strategies, focuses on detecting the virus by using affordable cost-high efficiency processes with the help of loop-mediated isothermal amplification (LAMP) analysis and screen printed electrodes (SPE) implemented on a commercial potentiostat. The device measures the current response generated from the interaction between the target molecules and the SPE using cyclic voltammetry (CV). The system (LAMP-EC) proposes a promising electrochemical sensor for the detection of TB that can be clinically adopted by dint to its feasibility and high sensitivity. Our purpose is to make it an integrated lab-on-chip quantitative rapid point-of-care in both high- and low-resource settings across the TB endemic regions.