EventsThe 16th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-16-01070
This submission belongs to the session a. General Organic Synthesis of the event The 16th International Electronic Conference on Synthetic Organic Chemistry
Published date
29 Oct, 2012
Citation
Giang Vo-Thanh, Houssein Ibrahim, Synthesis of Novel Chiral Monophosphine Ligands Derived from Isomannide and Isosorbide. Application to Enantioselective Hydrogenation of Olefins, in Proceedings of The 16th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2012, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-16-01070
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Synthesis of Novel Chiral Monophosphine Ligands Derived from Isomannide and Isosorbide. Application to Enantioselective Hydrogenation of Olefins

Houssein Ibrahim 1
Giang Vo-Thanh 1
1. University Paris-Sud 11
Abstract
A new class of monophosphine ligands has been prepared from naturally chirality renewable source, 1,4 :3,6-dianhydrohexitol compounds, via a nucleophilic substitution process or a hydrophosphination reaction involving microwave activation. These ligands have been evaluated for the rhodium-catalyzed enantioselective hydrogenation of olefins giving good conversion and enantioselectivity up to 95% and 96% ee, respectively.
Keywords
Monophosphine ligands
Isosorbide
Isomannide
Hydrogenation
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